Recurrent Autoimmune Hepatitis Post-Liver Transplant: What Are the Risks?

Younger age and use of a certain immunosuppressive agent were more than three times as likely to be associated with higher risk of recurrent autoimmune hepatitis (AIH) after liver transplantation, researchers found.

Among 736 AIH patients who received a liver transplant over a 33-year period, adjusted analyses showed the following factors were associated with a greater risk of recurrent disease:
– Age 42 or younger at transplantation (HR 3.15, 95% CI 1.22-8.16, P=0.02)
– Using mycophenolate mofetil after transplantation (HR 3.06, 95% CI 1.39-6.73, P=0.005)
– Sex mismatch between donor and recipient (HR 2.57, 95% CI 1.39-4.76, P=0.003)
– High IgG levels before transplantation (HR 1.04, 95% CI 1.01-1.06, P=0.004)
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