{"id":2191,"date":"2021-05-05T20:37:59","date_gmt":"2021-05-06T03:37:59","guid":{"rendered":"https:\/\/allocare.caredx.com\/?p=2191"},"modified":"2022-08-16T14:14:00","modified_gmt":"2022-08-16T21:14:00","slug":"antibody-response-to-2-dose-sars-cov-2-mrna-vaccine-series-in-solid-organ-transplant-recipients","status":"publish","type":"post","link":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/indexphp\/2021\/05\/05\/antibody-response-to-2-dose-sars-cov-2-mrna-vaccine-series-in-solid-organ-transplant-recipients\/","title":{"rendered":"Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients"},"content":{"rendered":"<span class=\"simplefavorite-button has-count loading\" data-postid=\"2191\" data-siteid=\"1\" data-groupid=\"1\" data-favoritecount=\"4\" style=\"\">Loading<span class=\"sf-icon-spinner-wrapper\"><i class=\"sf-icon-spinner\"><\/i><\/span><\/span>\n<p>&#8220;Transplant recipients without prior polymerase chain reaction\u2013confirmed COVID-19 were recruited from across the US to participate in this prospective cohort through a digital campaign. Those who completed the 2-dose SARS-CoV-2 mRNA vaccine series between December 16, 2020, and March 13, 2021, were included and followed up through April 13, 2021. As described previously,<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2779852?fbclid=IwAR1Gm4N0oDUXMV6rXhvhWlAjVKYrHDwKSauPl5zg2HKq7XpLWneTV4Kin3g#jld210032r3\">3<\/a><\/sup>\u00a0semiquantitative antispike serologic testing was undertaken with the Roche Elecsys anti\u2013SARS-CoV-2 S enzyme immunoassay, positive cutoff of at least 0.8 U\/mL, which tests for the receptor-binding domain of the SARS-CoV-2 spike protein, or the EUROIMMUN enzyme immunoassay, positive cutoff of at least 1.1 arbitrary units, which tests for the S1 domain of SARS-CoV-2 spike protein, both key measures of humoral immune response.<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2779852?fbclid=IwAR1Gm4N0oDUXMV6rXhvhWlAjVKYrHDwKSauPl5zg2HKq7XpLWneTV4Kin3g#jld210032r4\">4<\/a><\/sup><sup>,<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2779852?fbclid=IwAR1Gm4N0oDUXMV6rXhvhWlAjVKYrHDwKSauPl5zg2HKq7XpLWneTV4Kin3g#jld210032r5\">5<\/a><\/sup>\u00a0This study was approved by the Johns Hopkins institutional review board; participants provided informed consent electronically.<\/p>\n\n\n\n<p>The proportion of patients who developed a positive antibody response was assessed with an exact binomial confidence interval. The Fisher exact test was used to compare categorical variables, such as antimetabolite immunosuppression, and the Kruskal-Wallis test for continuous variables. All tests were 2-sided with \u03b1\u2009=\u2009.05. Analyses were performed using Stata 16.1\/Windows.&#8221;<\/p>\n\n\n\n<p>See the full study results, <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2779852?fbclid=IwAR1Gm4N0oDUXMV6rXhvhWlAjVKYrHDwKSauPl5zg2HKq7XpLWneTV4Kin3g\">here<\/a>.<\/p>\n<span class=\"simplefavorite-button has-count loading\" data-postid=\"2191\" data-siteid=\"1\" data-groupid=\"1\" data-favoritecount=\"4\" style=\"\">Loading<span class=\"sf-icon-spinner-wrapper\"><i class=\"sf-icon-spinner\"><\/i><\/span><\/span>","protected":false},"excerpt":{"rendered":"<p>Loading &#8220;Transplant recipients without prior polymerase chain reaction\u2013confirmed COVID-19 were recruited from across the US to participate in this prospective cohort through a digital campaign. Those who completed the 2-dose &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/indexphp\/2021\/05\/05\/antibody-response-to-2-dose-sars-cov-2-mrna-vaccine-series-in-solid-organ-transplant-recipients\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":1346,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":0,"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[912,9,29],"tags":[20,18,26,27,17,142],"post_format":[],"Dislikes":"","Likes":"","simplefavorites_count":"4","views":"1737","post_likes_plusCounter":"","post_dislikes_plusCounter":"","acf":[],"_links":{"self":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts\/2191"}],"collection":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/comments?post=2191"}],"version-history":[{"count":1,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts\/2191\/revisions"}],"predecessor-version":[{"id":2192,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts\/2191\/revisions\/2192"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/media\/1346"}],"wp:attachment":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/media?parent=2191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/categories?post=2191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/tags?post=2191"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/post_format?post=2191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}