{"id":1385,"date":"2021-01-11T12:50:15","date_gmt":"2021-01-11T20:50:15","guid":{"rendered":"https:\/\/allocare.caredx.com\/?p=1385"},"modified":"2022-08-16T14:14:31","modified_gmt":"2022-08-16T21:14:31","slug":"tonix-pharmaceuticals-and-massachusetts-general-hospital-mgh-enter-into-research-collaboration-on-tonixs-third-generation-anti-cd40-ligand-monoclonal-antibody-tnx-1500-for-the-treatment-a","status":"publish","type":"post","link":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/indexphp\/2021\/01\/11\/tonix-pharmaceuticals-and-massachusetts-general-hospital-mgh-enter-into-research-collaboration-on-tonixs-third-generation-anti-cd40-ligand-monoclonal-antibody-tnx-1500-for-the-treatment-and-prevention-of-kidney-transplant-rejection\/","title":{"rendered":"Tonix Pharmaceuticals and Massachusetts General Hospital (MGH) Enter into Research Collaboration on Tonix\u2019s Third Generation anti-CD40-Ligand Monoclonal Antibody, TNX-1500, for the Treatment and Prevention of Kidney Transplant Rejection"},"content":{"rendered":"<span class=\"simplefavorite-button has-count loading\" data-postid=\"1385\" data-siteid=\"1\" data-groupid=\"1\" data-favoritecount=\"1\" style=\"\">Loading<span class=\"sf-icon-spinner-wrapper\"><i class=\"sf-icon-spinner\"><\/i><\/span><\/span>\n<p>&#8220;Transplantation experts led by Tatsuo Kawai, M.D., Ph.D., Surgical Director of the Living Donor Transplantation and Dialysis Access Program at MGH and Professor of Surgery at Harvard Medical School (HMS) will study TNX-1500 in kidney transplantation in a variety of models including non-human primates. The goal of the collaboration is to advance TNX-1500 as a potential first-in-class therapeutic to prevent and treat kidney transplant rejection.<\/p>\n\n\n\n<p>Dr. Kawai said, \u201cAnti-CD40-ligand therapy has a unique activity in controlling the immune response to organ transplants.<sup>2<\/sup>\u00a0There remains a significant need for new treatments to reduce the toxicity of current treatments by more selectively suppressing immune responses or inducing specific tolerance to the transplanted organ. Anti-CD40-ligand has shown promise not only to effectively suppress rejection but also to facilitate \u2018transplant tolerance\u2019 in multiple preclinical transplant models.<sup>6<\/sup>\u201d<br><br>Read full article, <a href=\"https:\/\/finance.yahoo.com\/news\/tonix-pharmaceuticals-massachusetts-general-hospital-120000350.html\">here<\/a>.<\/p>\n<span class=\"simplefavorite-button has-count loading\" data-postid=\"1385\" data-siteid=\"1\" data-groupid=\"1\" data-favoritecount=\"1\" style=\"\">Loading<span class=\"sf-icon-spinner-wrapper\"><i class=\"sf-icon-spinner\"><\/i><\/span><\/span>","protected":false},"excerpt":{"rendered":"<p>Loading &#8220;Transplantation experts led by Tatsuo Kawai, M.D., Ph.D., Surgical Director of the Living Donor Transplantation and Dialysis Access Program at MGH and Professor of Surgery at Harvard Medical School &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/indexphp\/2021\/01\/11\/tonix-pharmaceuticals-and-massachusetts-general-hospital-mgh-enter-into-research-collaboration-on-tonixs-third-generation-anti-cd40-ligand-monoclonal-antibody-tnx-1500-for-the-treatment-and-prevention-of-kidney-transplant-rejection\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Tonix Pharmaceuticals and Massachusetts General Hospital (MGH) Enter into Research Collaboration on Tonix\u2019s Third Generation anti-CD40-Ligand Monoclonal Antibody, TNX-1500, for the Treatment and Prevention of Kidney Transplant Rejection&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":875,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":0,"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","_ecp_custom_2":"","footnotes":""},"categories":[45,912,1],"tags":[112,111,17],"post_format":[],"Dislikes":"","Likes":"","simplefavorites_count":"1","views":"1804","post_likes_plusCounter":"0","post_dislikes_plusCounter":"2","acf":[],"_links":{"self":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts\/1385"}],"collection":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/comments?post=1385"}],"version-history":[{"count":1,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts\/1385\/revisions"}],"predecessor-version":[{"id":1386,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/posts\/1385\/revisions\/1386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/media\/875"}],"wp:attachment":[{"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/media?parent=1385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/categories?post=1385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/tags?post=1385"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/app-allocare-wordpress-linux-prod.azurewebsites.net\/index.php\/wp-json\/wp\/v2\/post_format?post=1385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}