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Post-Transplant Diabetes Can Be Predicted in Kidney Recipients

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Researchers published the study covered in this summary on Research Square and it has not yet been peer reviewed.

Key Takeaways

  • A retrospective, case-control study of kidney transplant recipients in China identified that a combination of the following parameters can predict post-transplant diabetes mellitus (PTDM) diagnosed after 45 days:
    • Family history of diabetes mellitus.
    • Standard deviation of fasting plasma glucose when values are fluctuating (day 3 to day 11 post-transplant).
    • Maximum fasting plasma glucose when values have stabilized (week 3 to week 6 post-transplant).
      Read the full story in MedScape.
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Post-Transplant Diabetes Risk Informed by Polygenic Risk Profiles in Donors, Recipients

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NEW YORK – Taking organ donor and recipient genetics into consideration — via a polygenic risk score (PRS) — may help identify individuals at risk of developing diabetes after a solid organ transplant.

“Our study demonstrates the importance, and the potential application, of PRS in solid organ transplantation,” co-first and corresponding author Abraham Shaked, a researcher at the University of Pennsylvania’s Penn Transplant Institute, and his coauthors wrote in Nature Medicine on Thursday. Read the story in GenomeWeb here.

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Diabetes After a Transplant

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What is “new-onset diabetes” after transplant?

Even if you did not have diabetes before, you may develop diabetes after an organ transplant. This type of diabetes is called “new-onset diabetes” after transplant. It is also called “NODAT” for short. New-onset diabetes can occur as a side effect of the medications that you need to prevent rejection of your new organ. Read more.

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