COVID-19 Mortality Risk Factors in Kidney Transplant Recipients Identified

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Investigators have identified risk factors for COVID-19-related mortality among kidney transplant recipients, including intubation and mechanical ventilation.

Among 218 kidney transplant recipients diagnosed with COVID-19 at a single center in India from April 2020 to July 2021, 30 died. Investigators matched and compared the 30 deceased patients with 188 survivors by age, sex, blood group, living or deceased donor transplant type, transplant duration, comorbidities, immunosuppression, hospitalization vs home care, and history of graft function, infections, acute kidney injury, and related therapies. Read more in Renal & Urology News.

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Researchers recommend kidney transplant recipients continue getting COVID-19 vaccinations

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Although COVID-19 vaccines lower the risk of infection among kidney transplant recipients, breakthrough infections can occur, and researchers recommend patients continue to receive boosters when available.

“The SARS-CoV-2 messenger RNA (mRNA) vaccines have shown high clinical efficacy in preventing COVID-19 in the immunocompetent population,” Ivan Zahradka, MD, from the Institute for Clinical and Experimental Medicine in the Czech Republic, and colleagues wrote. They added, “However, data about the effectiveness of SARS-CoV-2 vaccines are conflicting, and to what extent the two doses of an mRNA vaccine protect [kidney transplant recipients] KTRs from COVID-19 is unclear.” Read the full story in Healio.

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Inflammation Associated with Mortality in Kidney Transplant Recipients

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No specific inflammatory pathway was considered causative to long-term mortality in kidney transplant recipients.

Investigators observed strong association between low-grade systemic inflammation in the 10 weeks following kidney transplantation and long-term mortality in a recent cohort study from Norway.

Generally, low-grade systemic inflammation has been established as a risk factor for all-cause mortality as has been known to increase the severity and risk of diseases including cardiovascular disease and cancer. Read more on HCP Live.

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Kidney transplant recipients were more careful than the general population during pandemic

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During the first few waves of COVID-19, kidney transplant recipients in Norway engaged in less social interaction than the general population and strongly adhered to government advice, according to data published in Kidney Medicine.

Further, kidney transplant recipients reported feeling more concerned about infections despite living in a country with low infection rates. Read more.

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