Short and Long-Term Outcomes of Kidney Transplant Recipients Diagnosed With COVID-19 Infection: A Single-Center Observational Study

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Abstract

Purpose: Kidney transplant recipients (KTRs) are at an increased risk of severe disease and death caused by coronavirus disease 2019 (COVID-19) infection. There is a paucity of information on the evolution of graft function among hospitalized KTRs who overcome the infection.

Methods: The study included adult KTRs at a single transplant institute who were diagnosed with COVID-19 and needed hospitalization between March 15, 2020, and January 15, 2021. We analyzed patient demographics, comorbid risk factors, and inpatient clinical courses for patients who were able to recover from the infection. Kidney function was analyzed pre-infection, during initial hospitalization, and up to 12 months post-infection. Read the full study in Cureus.

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Kidney Transplant Recipients Have Insufficient Immunity During COVID-19 Illness

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Investigators have found evidence of reduced T cell immunity during COVID-19 illness followed by T cell recovery in kidney transplant recipients. Insufficient immunity appears to occur despite initial reduction of antirejection medications in these patients.

Most centers have empirically reduced anti-rejection immunosuppression in kidney transplant recipients with COVID-19 due to concerns that immunosuppressant use would hinder anti-COVID-19 immunity, Madhav C. Menon, MBBS, of Yale University in New Haven, Connecticut, and colleagues explained in theĀ Journal of the American Society of Nephrology. Read the full story in Reanl & Urology News.

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Kidney Transplant Recipients Have Insufficient Immunity During COVID-19 Illness

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Investigators have found evidence of reduced T cell immunity during COVID-19 illness followed by T cell recovery in kidney transplant recipients. Insufficient immunity appears to occur despite initial reduction of antirejection medications in these patients.

Most centers have empirically reduced anti-rejection immunosuppression in kidney transplant recipients with COVID-19 due to concerns that immunosuppressant use would hinder anti-COVID-19 immunity, Madhav C. Menon, MBBS, of Yale University in New Haven, Connecticut, and colleagues explained in theĀ Journal of the American Society of Nephrology. Read more in Renal & Urology News.

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