Sparsentan Failed to Preserve Kidney Function Over Time in FSGS

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— However, more patients on the drug achieved partial remission of proteinuria vs irbesartan

By Kristen Monaco

PHILADELPHIA — Treatment with sparsentan (Filspari) led to no significant differences in estimated glomerular filtration rate (eGFR) slope compared with irbesartan among patients with focal segmental glomerulosclerosis (FSGS), the phase III DUPLEX trial showed.
Read the full article in MedPage Today.

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VUMC adopts updated kidney function equation to better guide patient care decisions

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by Jill Clendening

In July 2020, Vanderbilt University Medical Center was one of the first institutions in the United States to remove race from an equation used to estimate kidney function through the calculation of an estimated glomerular filtration rate (eGFR), and in December the Medical Center will again update the equation used for calculating eGFR with the goals of improving health equity and better guiding patient care decisions. Read the full story in the VUMC Reporter.

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Johns Hopkins Health System Adopts Race-Free Kidney Function Equation

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Newswise — The Johns Hopkins Health System will no longer use a long-standing clinical standard that factors a patient’s race into kidney function tests. The transition to a new standard of evaluating kidney function will specifically eliminate whether a patient is “African American or non-African American” as a modifier to check how well a patient’s kidneys are working. The change to the new race-neutral assessment means thousands of Black people living with chronic kidney disease (CKD) could gain access to specialty treatment or transplantation for the first time.

Removing race from the calculation for kidney disease follows recent national recommendations from both the National Kidney Foundation and the American Society of Nephrology that say race modifiers should not be included in equations used to estimate kidney function because race is a social, not a biological, construct. Read the full story here.

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