COVID Heart Injuries Traced Back to Infected Arterial Plaque, Inflammation

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— SARS-CoV-2 persistence in some vascular cells may have ties to long COVID

By Nicole Lou

Scientists found that the SARS-CoV-2 virus can directly infiltrate atherosclerotic plaques in coronary arteries and trigger an inflammatory response, providing one mechanism for how COVID-19 infection can lead to cardiovascular complications in some people.

Directly infected atherosclerotic tissue was found in both people who died with severe COVID-19 and underlying atherosclerosis and an ex vivo model of human vascular explants.
Read the complete article in MedPage Today.

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U.S. FDA authorizes COVID-19 vaccine boosters for the immunocompromised

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“The U.S. Food and Drug Administration authorized a third dose of COVID-19 vaccines from Pfizer Inc (PFE.N) and Moderna Inc (MRNA.O) for people with compromised immune systems.

The amended emergency use authorization paves the way for people who have had an organ transplant, or those with a similar level of weakened immune system, to get an extra dose.

“After a thorough review of the available data, the FDA determined that this small, vulnerable group may benefit from a third dose of the Pfizer-BioNTech or Moderna vaccines,” Janet Woodcock, U.S. FDA’s acting commissioner, said in a tweet on Thursday.”

Read more, here.

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They Survived COVID. Now They Need New Lungs.

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“BOSTON — He survived Covid-19, but his lungs were ravaged. After months of deep sedation, he is delirious, his muscles atrophied. And this 61-year-old still cannot breathe on his own.

He was first intubated just after the winter holidays. Now, when he fully wakes, he will see that he is still attached to the ventilator by a tracheostomy tube in his neck. Slowly, he will come to learn that catheters the size of garden hoses are connecting his body to another device, a large extracorporeal membrane oxygenation machine that has taken over the work of his failed lungs.

Gently, his doctors and family will tell him that his lungs are never going to recover, and that this machine is a bridge that will help keep him alive until he can receive a transplant. If it turns out that he is not a transplant candidate — if he cannot build up enough strength, or if he develops a catastrophic new infection or organ failure — the machine will eventually be turned off. And he will die.

He is not alone. Here in my hospital, we are caring for a new population of patients who have cleared the virus but are left with severe lung disease, trapped on ventilators and lung bypass machines.”

Read the full piece, here.

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