An FDA advisory committee almost unanimously agreed that the risks were just too high for the chronic kidney disease (CKD)-related anemia drug roxadustat in any patient population.
In a 13-1 vote Thursday, members of the Cardiovascular and Renal Drugs Advisory Committee felt that although there’s an unmet need for new anemia therapeutics, this particular drug carried too strong of a safety signal for thrombotic risk in a non-dialysis dependent patient population.
Read more, here.
Regardless of anemia, iron deficiency in patients with late-stage chronic kidney disease (CKD) was linked with adverse health outcomes, an observational study found.
In 5,145 patients with stage 3-5 CKD not on dialysis, a transferrin saturation (TSAT) of 15% or less was associated with a higher risk for all-cause mortality before reaching dialysis or kidney transplant, as compared to TSAT levels of 26-35% (HR 1.44, 95% CI 1.03-2.01), according to Roberto Pecoits-Filho, MD, PhD, of the Arbor Research Collaborative for Health in Ann Arbor, Michigan, and colleagues.
Read more, here.
“FDA has approved Kerendia (finerenone) tablets to reduce the risk of kidney function decline, kidney failure, cardiovascular death, non-fatal heart attacks, and hospitalization for heart failure in adults with chronic kidney disease associated with type 2 diabetes.
Diabetes is the leading cause of chronic kidney disease and kidney failure in the United States. Chronic kidney disease occurs when the kidneys are damaged and cannot filter blood normally. Because of defective filtering, patients can have complications related to fluid, electrolytes (minerals required for many bodily processes), and waste build-up in the body. Chronic kidney disease sometimes can progress to kidney failure. Patients also are at high risk of heart disease.”
Read the full report by the FDA, here.
“Pain is common among patients with stage 3 or higher chronic kidney disease (CKD), those receiving dialysis, and kidney transplant recipients, a new study finds.
In a systematic review and meta-analysis involving 116 studies and 40,678 individuals, 60% had pain, 48% had chronic pain lasting more than 3 months, and 10% had neuropathic pain, Samira Bell, MB ChB, of the University of Dundee in Scotland and colleagues reported in Kidney International.
Overall pain prevalence was lower among kidney transplant recipients (46%) compared with patients undergoing dialysis (63%) and patients with nondialysis CKD (63%). Individuals on hemodialysis and peritoneal dialysis had similar pain prevalence. Among patients with nondialysis CKD, those with stage 3 or 4 disease reported pain as often as those with stage 5 disease, probably because these patients received palliative care, according to the investigators.”
Read the full article, here.
“Rates of use of emergency departments (ED) and hospital admission are high among patients with chronic kidney disease (CKD), particularly among patients with CKD requiring dialysis. Patients receiving maintenance dialysis have, on average, three visits to the ED per year, a rate that is three to eight times higher than among the general population. Of those ED visits, a significant proportion result in hospital admission. Further, ED and in-patient care are drivers of medical costs for patients with CKD, and are associated with significant emotional burden for patients and their caregivers.”
Read more, here.
If you play basketball for a prestigious program like the University of Southern California (USC) or professionally in China and Europe, it’s a pretty good bet you are an athlete at the top of your game.
Chronic kidney disease (CKD) is just not something that should rear its ugly head if your life is about proper nutrition, consistent exercise, and high-level competition.
Right?
Tiffany Archibald would beg to differ.
Read Tiffany’s full story, here.
“A new guideline from the Kidney Disease: Improving Global Outcomes (KDIGO) group addressing issues around diabetes management in patients with chronic kidney disease (CKD) has just been published in synopsis form in Annals of Internal Medicine.
The full guideline, including 12 recommendations and 48 practice points for clinicians caring for patients with diabetes and CKD, was published last month in Kidney International and on the KDIGO website.
More than 40% of people with diabetes develop CKD, and a significant number develop kidney failure requiring dialysis or transplant. This is the first guidance from KDIGO to address the comorbidity.”
Read more, here.
“Grocery shopping has become an increasing challenge during this pandemic. When you have CKD, wondering what to buy when food supplies may be limited can be overwhelming. Buying staples that fit your CKD needs while maintaining your budget can be challenging. This tip sheet will help you with some ideas if you can’t get fresh or frozen items.”
Read the full blog post on KIDNEYCHEF and see the list of staple, here.