Inflammatory mediators could provide link between obesity, CKD

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By David Statman

PHILADELPHIA — The association between obesity and chronic kidney disease may be partially explained by inflammatory cytokines and high levels of leptin, according to data from a study presented at ASN Kidney Week.

The data showed that inflammatory and proinflammatory mediators were highest in obese patients, with maximum aberrations occurring in obese patients with CKD, suggesting a potential link. Read the article in Healio.

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Kidney Week Roundup: Cell Therapy Cuts Immunosuppressive Drug Use Post-Transplant

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— Plus: bardoxolone methyl for diabetic kidney disease and spironolactone in hemodialysis patients

By Kristen Monaco

PHILADELPHIA — Some of the latest research in the field of nephrology presented at the American Society of Nephrology’s Kidney Week included sparsentan in focal segmental glomerulosclerosis, combination treatment with an SGLT2 inhibitor and an endothelin A receptor antagonist, and a novel aldosterone synthase inhibit in chronic kidney disease. Below are a few more highlights.
Read the full story in MedPage Today.

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Kidney transplantation turns back the clock on renal aging

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By Tarun Sai Lomte

In a recent study published in the Journal of Internal Medicine, researchers observe that kidney transplantation (KT) mitigates the effects of renal aging.

Treating chronic kidney disease

Chronic kidney disease (CKD) is an age-related disease and exhibits an accelerated aging phenotype. The reduced clearance of uremic toxins during CKD results in the accumulation of toxic solutes that contribute to endothelial dysfunction, chronic inflammatory burden, and increased oxidative stress. Read the full article in News Medical Life Sciences.

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Chronic Kidney Disease Podcast

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When Is It Time to Talk About Kidney Transplantation?

By Matthew A. Sparks, MD; Samira S. Farouk, MD, MSCR

This transcript has been edited for clarity.

Matthew A. Sparks, MD: I’m Dr Matthew Sparks. Welcome to Medscape’s InDiscussion series on chronic kidney disease. Today we’ll be discussing kidney transplantation with my guest, Dr Samira Farouk. Dr Farouk is an associate professor of medicine and medical education and a transplant nephrologist at the Icahn School of Medicine at Mount Sinai. She is also the associate program director of the fellowship program. Check out the complete podcast in Medscape.

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Only 40% of Diabetes Patients Get Recommended Kidney Health Testing

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~ Study Reveals Alarming Disparities in Chronic Kidney Disease Testing and Highlights Path to Equitable Care for Americans living with Diabetes ~

(August 30, 2023, New York, NY) — Not enough diabetes patients are getting their recommended kidney health screenings, according to a new study by the National Kidney Foundation (NKF) and the National Committee for Quality Assurance (NCQA).

According to new data published in Mayo Clinic Proceedings: Innovations, Quality & Outcomes journal, less than 40% of patients with diabetes have been recommended at least annual kidney health screening tests. Diabetes raises the risk of chronic kidney disease (CKD), a serious condition that often remains asymptomatic until reaching an advanced stage. Read more from the National Kidney Foundation.

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Psychological distress may be linked to poor self-management of chronic kidney disease

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By Shawn M. Carter

Psychological distress may be linked to poor self-management of chronic kidney disease, according to a recently published study of patients with CKD who were not on dialysis.

“Beginning with the diagnosis of chronic kidney disease (CKD) onward, patients are confronted with profound changes that require extensive emotional skills. An additional burden is adhering to disease self-management recommendations,” lead researcher Cinderella K. Cardol, PhD, of the health, medical and neuropsychology unit at Leiden University in The Netherlands, and colleagues wrote. 
Read the full story in Healio.

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Payers, providers see value-based care as opportunity to treat early stages of CKD

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By Mark E. Neumann

One goal of the Advancing American Kidney Health initiative, which was launched in 2019, was to significantly increase the number of kidney transplants.

The way to do that, according to CMS at the time, was to intervene early and slow chronic kidney disease progression so preemptive transplants could be performed, allowing patients to forgo dialysis.
Read the full story in Healio.

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Experts Outline Strategies for Boosting Equity in Chronic Kidney Disease

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— Race-neutral calculations for kidney function, leveling the playing field on waiting lists

By Shannon Firth

Physicians and advocates explored ways to improve access to clinical trials, dialysis, and transplants for racial and ethnic minorities with chronic kidney disease during a webinaropens in a new tab or window hosted by U.S. News & World Report and sponsored by the American Kidney Fund (AKF).

When the COVID-19 pandemic struck, people with chronic kidney disease, particularly those in kidney failure, could not isolate the way other people could because they needed to go to dialysis or other medical appointments, explained LaVarne Burton, president and CEO of the AKF.
Read the full article in MedPage Today.

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