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Young Man Becomes First in World to Be Cured of FSGS With New Treatment

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Combined stem cell transplant and kidney transplant prove a winning combination against autoimmune FSGS

Imagine spending a good share of your childhood hooked up to a machine. While your friends are traveling on a bus to a school game or hanging out at the mall, you are at home or at a dialysis center tethered by cords, every day for at least three hours. A lot of kids would give up trying to keep up with life. Not 21-year-old Traejen Kingston. 
Read the full story from Stanford Children’s Health.

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Man is oldest person possibly cured of HIV after stem cell transplant

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A 66-year-old man is the oldest person yet to possibly be cured of HIV after undergoing a stem cell transplant, researchers announced Wednesday.

The man had HIV for more than 31 years when he received a blood stem cell transplant in early 2019 for acute myeloid leukemia (AML) using cells from a donor with a rare genetic mutation that prevents HIV from entering human cells, making people who have it resistant to most strains of the virus. Read more in Healio.

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Longtime HIV patient is effectively cured after stem cell transplant

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The man is among a handful who have gone into remission after the procedure, but it is not an option for most people with the virus

A 66-year-old man with HIV is in long-term remission after receiving a transplant of blood stem cells containing a rare mutation, raising the prospect that doctors may someday be able to use gene editing to re-create the mutation and cure patients of the virus that causes AIDS, a medical team announced Wednesday.
Read the full article in The Washington Post.

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Allogeneic Stem Cell Transplant Outcomes Improve With Diverse Gut Microbes, Immune Cells

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NEW YORK – A team from Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, and elsewhere has demonstrated that interactions between the gut microbial community and the immune system can influence an individual’s response to a bone marrow transplant to treat leukemia, lymphoma, multiple myeloma, and other blood conditions.

Past studies have suggested ties between microbial diversity and favorable allogeneic hematopoietic stem cell transplantation (allo-HCT) outcomes, or transplants involving stem cells from healthy donors. For their new study, the researchers set out to characterize fecal microbiome features alongside immune cell features and clinical outcomes in allo-HCT recipients — work they presented in Science Translational Medicine on Wednesday.
Read more in GenomeWeb.

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Donor socioeconomic status affects hematopoietic stem cell transplant outcomes

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SALT LAKE CITY — Socioeconomic disadvantage among hematopoietic stem cell transplant donors appeared associated with poorer outcomes among transplant recipients, according to study results.

The findings — presented at Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR — indicate a biologic impact of socioeconomic status on hematopoietic cells that is transferrable from HSCT donor to recipient, researchers concluded. Read more in Healio.

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Impact of Race and Geographic Area of Residence on Outcomes After Allogeneic Stem Cell Transplant

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Front Oncol. 2022 Feb 25;12:801879. doi: 10.3389/fonc.2022.801879. eCollection 2022.

ABSTRACT

BACKGROUND: Allogeneic hematopoietic stem cell transplant (allo-HCT) is a potential curative therapy for a variety of hematologic disorders. However, it requires highly specialized care that is only available at select centers across the country. Thus, minority populations are at risk for healthcare disparities in access to and outcomes of allo-HCT. Our study aimed to assess the impact of race and location of residence on outcomes of allo-HCT. Read more.

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Researchers report third case of HIV remission after stem cell transplant using umbilical cord blood

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(CNN)A US woman has become the third known person who’s gone into HIV remission, and the first mixed-race woman, thanks to a transplant of stem cells from umbilical cord blood, according to research presented at a conference Tuesday.

The woman, whom the researchers described as middle-aged and of mixed race, was diagnosed with acute myeloid leukemia four years after an HIV diagnosis, according to an abstract from the Conference on Retroviruses and Opportunistic Infections.
Read the full story.

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A Twist on Stem Cell Transplants Could Help Blood Cancer Patients

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CATHY DOYLE FELT fine. And in April 2016, when she logged in to a web portal to check the results of some routine blood work, the little numbers on the screen agreed—mostly. But her white blood cell count looked low. She called the doctor’s office. “What’s going on?” the chatty, spiritual 58-year-old from Pittsburgh remembers saying.

The staff asked if she’d recently been sick. She had. Doyle caught a bad cough on a family cruise, but it had passed. That might be it, they agreed, but it would be best to come in for more blood tests. “Bless the doctor,” Doyle says. “He just kept hoping it wouldn’t be leukemia.” Read more here.

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