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Pediatric Kidney Transplant Rate Lower at For-Profit Dialysis Facilities

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Children receiving maintenance dialysis have lower rates of pediatric transplant waitlisting and kidney transplantation at facilities that are for-profit rather than nonprofit, according to an analysis of data from the US Renal Data System.

Among 13,333 pediatric patients with end-stage kidney disease (ESKD) who initiated dialysis during 2000-2018, 3618 (27%) attended for-profit facilities, 7907 (59%) attended nonprofit facilities, and 1748 (13%) switched profit status. Read more in Renal & Urology News.

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Pediatric kidney transplant patients fare better when kidney is from live donor

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(SACRAMENTO) Do pediatric kidney transplant patients have better long-term outcomes when their kidney comes from living, biologically unrelated donors compared to deceased donors?

A new UC Davis Health study finds that they do. The study reviewed data from the Organ Procurement & Transplantation Network database from Jan. 1, 2001 to Sept. 30, 2021. Researchers compared the rates of graft failure (when the organ is rejected by the recipient) and death, as well as long-term outcomes of children who received kidney transplants from living related donors, living unrelated donors and deceased donors.
Read more from UC Davis Health News.

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Kids Treated at For-Profit Dialysis Centers Less Likely to Receive Transplant

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— They also waited longer to be put on a waitlist

Children receiving dialysis at a for-profit facility were less likely to be put on the waitlist for — and ultimately receive — a kidney transplant, according to a retrospective cohort study.

Among over 13,000 pediatric patients, those receiving dialysis at a profit center had a 21% lower chance of being put on the waitlist for a kidney versus those receiving care at nonprofit facilities (adjusted HR 0.79, 95% CI 0.75-0.83), reported Sandra Amaral, MD, MHS, of the Children’s Hospital of Philadelphia, and colleagues.
Read the full story in MedPage Today.

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Anemia Following Pediatric Kidney Transplant

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Among recipients of pediatric kidney transplantation, the prevalence of posttransplant anemia (PTA) ranges from 22% to 85%. PTA is defined as early (within 6 months of following transplant) or late (>6 months following transplant). In Frontiers in Pediatrics, Anne Kouri, MD, MS, and colleagues in the department of pediatrics, University of Minnesota, Minneapolis, describe the etiologies and management of PTA [doi:10.3398/fped.2022.929504]. Read more in Nephrology Times.

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Race disparities persist for stroke outcomes after pediatric cardiac transplant

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Among pediatric cardiac transplant recipients who experience perioperative stroke, Black children are three times more likely to die beyond 6 months compared with white children, according to data from a registry analysis.

In a database analysis of pediatric transplants in the United States, researchers also found that Black children have a lower incidence of stroke after cardiac transplant compared with white children, and that mortality among survivors of perioperative stroke is initially similar by race and ethnicity. Read the full story in Healio.

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Physicians Transplant Kidneys into Children Without Immune Suppressing Drugs

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​Three pediatric patients with a rare genetic disease that causes kidney failure have successfully been treated with transplanted kidneys without using anti-rejection drugs or treatments.

Experts at Stanford University treated three children with a rare condition called Schimke immuno-osseous dysplasia (SIOD). This genetic condition not only causes a weakened immune system but also causes kidney disease, according to the Genetic and Rare Diseases Information Center at the NIH. Read more in Healthline.

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‘I Can’t Wait to Swim!’ | How a Kidney Transplant Changed the Possibilities for 4-Year-Old Stella

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“She has so much more energy and is eating so much more. She is also moving and walking more than she ever did.”

Four-year-old Stella Allison has always loved telling jokes and playing dress up.

With energy that is contagious and a smile that lights up a room, her mom Kyley Barthlow says Stella has grown into a high-spirited and chatty child – but was born a real fighter.
Read the full story from Seattle Children’s.

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Immunosuppression Adherence in Pediatric Kidney Transplant

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Following solid-organ transplantation, the primary aim of care is preventing allosensitization. Despite potent immunosuppression, nonadherence often disrupts treatment, resulting in rejection. Among recipients of kidney transplant, the strongest predictors of allograft failure are nonadherence and subsequent antibody or T-cell-mediated rejection (AMR and TCMR, respectively). Read more in Nephrology Times.

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Pediatric transplant patients may skip adult appointments

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Study finds more than one in four patients attend an average of less than one appointment per year

Young adults who received organ transplants as children may not be regularly attending their doctor appointments after leaving their pediatric providers. Missing these appointments is associated with longer and more frequent hospitalizations and poorer medication adherence, according to a new study. Read the full story in UGA Today.

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Video therapy improves medication adherence for adolescent heart transplant recipients

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A digital medication adherence program with virtual video check-ins was associated with adolescent heart transplant recipients taking more of their medications as prescribed 6 months after the intervention, data from a pilot study show.

“Medication nonadherence is a significant problem which can lead to graft failure and patient mortality,” Dipankar Gupta, MBBS, DCH, MD, assistant professor of pediatric cardiology at the Congenital Heart Center at UF Health Shands Children’s Hospital, University of Florida, told Healio. Read the full story in Healio.

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