Increased Rates of Heart Transplants in Patients With a Malignancy History

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Over the past 2 decades, the rate of heart transplantation among patients with pretransplant malignancy (PTM) has increased dramatically. Although heart transplant recipients with a prior malignancy may be at an increased risk for early mortality, particularly those with a hematologic cancer, death rates after the first posttransplant year are comparable between patients with and without PTM. Results of an analysis of this patient population were published in the journal Circulation: Heart Failure.

A contemporary retrospective analysis of adults in the United Network for Organ Sharing registry was conducted among patients with PTM who had received heart transplantation between January 1, 2010, and December 31, 2020. Read more.

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Study compares heterologous and homologous third vaccination in kidney transplant recipients

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As of February 28, 2022, coronavirus disease 2019 (COVID-19) has caused over 5.95 million deaths worldwide, with especially high rates of mortality reported among the elderly, frail, and immunocompromised.

Kidney transplant recipients are among the most at-risk individuals of COVID-19 due to the need for long-term immunosuppressive medication to avoid rejection. Their response to vaccination is also poor, and researchers continue to examine methods to achieve a better vaccine response in this population. Read more.

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By altering the blood type of lungs, researchers raise the possibility of universal organs for transplants

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t was 4 a.m. on a humid night in St. Catharines, Ontario, and Elizabeth Ostrander couldn’t breathe. Chronic obstructive pulmonary disease, complicated by pneumonia, was suffocating her, doctors told her that day in 2016. If she hadn’t gotten to the hospital when she did, she would have died, Ostrander remembers them saying. She was in her early 50s.
Read the full story here.

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THINKER-NEXT Studies the Transplant of HCV-Infected Kidneys

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The next stage of the THINKER project — THINKER-NEXT — is aiming to settle any lingering concerns that patients and centers might have about using kidneys from hepatitis C (HCV)-infected donors and transplanting them into HCV-negative recipients in need of a kidney transplant.

Armed with an $8 million grant from the National Institutes of Health, researchers at the University of Pennsylvania in Philadelphia will evaluate the long-term risks and benefits of transplanting kidneys from HCV-positive donors into HCV-negative recipients and compare outcomes with those attained following transplantation of HCV-negative kidneys into HCV-negative recipients. Read more.

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(Opinion) Missy Franklin: No one should die waiting for a lifesaving organ transplant

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As the world continues to battle with a staggering pandemic that understandably has captured nearly every aspect of medical news, millions of people fight battles as before with major illnesses like cancer and heart disease. Among the many Americans currently suffering from potentially fatal medical conditions are those waiting for kidney, liver, or other organ transplants.

My dad Dick and aunt (and godmother) Deb are two of them. My family suffers from Polycystic Kidney Disease or PKD, a genetic disorder that reduces kidney function. Nearly half of those with PKD have kidney failure by age 60, and my father and aunt are in end-stage renal failure now. They are on the transplant list awaiting new kidneys. Read more.

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Robotic kidney transplant opens door to patients with a higher BMI

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UCHealth University of Colorado Hospital on the Anschutz Medical Campus (UCH) has become the nation’s fourth medical center – and the first west of the Mississippi – to perform a kidney transplant on a high-BMI patient using a surgical robot.

The surgery, performed by University of Colorado School of Medicine transplant surgeon Dr. Thomas Pshak on Nov. 17, was the culmination of two years of preparation, and it bodes well for those who otherwise wouldn’t be able to get kidney transplants at all.
Read more.

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Researchers use CareDx solutions to monitor first successful heart xenotransplantation

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CareDx Inc. announced its non-invasive organ transplant surveillance solutions were used to monitor postoperative graft health in the first successful heart xenotransplantation.

According to the press release, surgeons from the University of Maryland School of Medicine (UMSOM) are using versions of two Care-Dx surveillance solutions to monitor the genetically modified pig heart they transplanted into a patient on Jan. 7, 2022. Read more.

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Obesity may increase diabetic kidney disease risk, especially in women

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Adults with type 2 diabetes and a higher BMI may have an increased risk for diabetic kidney disease, according to study findings published in The Journal of Clinical Endocrinology Metabolism.

In findings from a generalized summary Mendelian randomization using 56 BMI-associated single nucleotide polymorphisms instrument variables, increasing BMI was linked to an increased risk for diabetic nephropathy and a lower estimated glomerular filtration rate, with the effects most pronounced among women. Read more.

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