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FDA approves teplizumab to delay type 1 diabetes onset

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The FDA has approved teplizumab to delay the onset of type 1 diabetes for both adults and children aged 8 years and older with stage 2 type 1 diabetes, according to an agency press release.

Tzield (teplizumab-mzwv, Provention Bio) injection is a humanized anti-CD3 monoclonal antibody designed to delay the development of type 1 diabetes in high-risk adults and children. “Tzield may deactivate the immune cells that attack insulin-producing cells, while increasing theproportion of cells that help moderate the immune response,” according to the release. Read more in Healio.

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New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review

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Abstract

A frequent complication in kidney transplantation is post-transplant diabetes mellitus (PTDM). The primary goal of this study is to review the risk factors and preventive methods and compare the different available anti-diabetic medications for the management of PTDM. We searched databases like Pubmed and Google Scholar for related articles using specific terms and phrases. Following a thorough investigation, we applied the inclusion and exclusion criteria and completed a quality assessment.
Read the full abstract in Cureus.

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Type 2 diabetes remission likely for adults with ‘healthy’ BMI and 10% weight loss

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Adults with type 2 diabetes and a BMI of 21 kg/m2 to 27 kg/m2 have high likelihood of diabetes remission if they lose 10% of their starting weight, researchers reported.

“Type 2 diabetes is often considered to be ‘caused’ by a higher body mass index, and certainly there is a strong link between increasing weight, increasing BMI and the incidence of type 2 diabetes,” Alison C. Barnes, RD, lead research associate and dietitian at the Human Nutrition Research Centre at Newcastle University, Newcastle upon Tyne, U.K., said during a presentation at the European Association for the Study of Diabetes annual meeting. Read more from Healio.

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Managing and Preventing Diabetes After an Organ Transplant

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Complications of posttransplant diabetes mellitus can develop quickly, but appropriate management may prevent them.

People with end-stage kidney disease achieve better quality of life and survival rates with a kidney transplant than with dialysis, but if they develop posttransplant diabetes mellitus (PTDM), they are at high risk for rapidly developing cardiovascular disease or other complications. Maria Paula Martinez-Cantarin, MD, a nephrologist and researcher at Thomas Jefferson University, describes how physicians can manage PTDM and prevent complications. Read the full article from National Institute of Diabetes and Digestive and Kidney Diseases.

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Type 2 diabetes remission likely for adults with ‘healthy’ BMI and 10% weight loss

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Adults with type 2 diabetes and a BMI of 21 kg/m2 to 27 kg/m2 have high likelihood of diabetes remission if they lose 10% of their starting weight, researchers reported.

“Type 2 diabetes is often considered to be ‘caused’ by a higher body mass index, and certainly there is a strong link between increasing weight, increasing BMI and the incidence of type 2 diabetes,” Alison C. Barnes, RD, lead research associate and dietitian at the Human Nutrition Research Centre at Newcastle University, Newcastle upon Tyne, U.K., said during a presentation at the European Association for the Study of Diabetes annual meeting. Read more in Healio.

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Diabetes-Related CKD Rates Dropped Slightly in Recent Years

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— But high incidence, especially in certain racial groups, remains a concern

Rates of chronic kidney disease (CKD) in people with diabetes have dipped in recent years but still remain high, researchers reported.

Between 2015 and 2020, the incidence of CKD among those with diabetes dropped by an estimated 17.6 cases per 1,000 person-years, Katherine R. Tuttle, MD, of Providence Health in Spokane, Washington, and colleagues wrote in a New England Journal of Medicine correspondence. Read the full story in MedPage Today.

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Post-Transplant Diabetes Can Be Predicted in Kidney Recipients

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Researchers published the study covered in this summary on Research Square and it has not yet been peer reviewed.

Key Takeaways

  • A retrospective, case-control study of kidney transplant recipients in China identified that a combination of the following parameters can predict post-transplant diabetes mellitus (PTDM) diagnosed after 45 days:
    • Family history of diabetes mellitus.
    • Standard deviation of fasting plasma glucose when values are fluctuating (day 3 to day 11 post-transplant).
    • Maximum fasting plasma glucose when values have stabilized (week 3 to week 6 post-transplant).
      Read the full story in MedScape.
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Risks for heart disease, disability, death higher with younger age at diabetes diagnosis

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The risk for heart disease, stroke, disability and mortality among adults with diabetes is higher for those diagnosed at age 50 to 59 years than those diagnosed at age 70 years or older, according to study findings.

In an analysis of data from adults aged 50 years and older participating in the Health and Retirement Study in the U.S., adults who reported they were diagnosed with diabetes at age 50 to 59 years had an increased risk for heart disease, stroke, disability, cognitive impairment and mortality compared with matched controls without diabetes, whereas adults diagnosed at age 70 years or older had a higher risk for only mortality compared with controls. Data did not distinguish between type 1 and type 2 diabetes.
Read the full story in Healio.

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Age at Diabetes Onset Matters for Death, Comorbidity Risks

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— Adults diagnosed in their 50s saw far worse outcomes than those diagnosed in their 70s

Age at diabetes diagnosis was predictive of morbidity and mortality in older adults, according to data from a population-based, biennial longitudinal health interview survey.

Of 7,739 adults ages 50 and older who participated in the Health and Retirement Study survey, diabetes diagnosis at 50 to 59 years of age was significantly associated with mortality (HR 1.49, 95% CI 1.29-1.71) compared with no diabetes diagnosis, reported Judy Zhong, PhD, of NYU Grossman School of Medicine in New York City, and colleagues in JAMA Network Open. Read the full story in MedPage Today.

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