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‘Complex’ relationship between obesity, CKD requires early, aggressive treatment

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Increased fat mass, particularly visceral adiposity, promotes kidney disease generation and progression through direct and indirect mechanisms, and pharmacologic treatment is necessary to avoid adverse outcomes, according to a speaker.

“The direct mechanisms that you and I treat in the office everyday are BP, cholesterol and diabetes,” Matthew Weir, MD, professor and chief of the division of nephrology at University of Maryland School of Medicine, said during a presentation at the World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease. Read more in Healio.

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Diabetes-Related CKD Rates Dropped Slightly in Recent Years

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— But high incidence, especially in certain racial groups, remains a concern

Rates of chronic kidney disease (CKD) in people with diabetes have dipped in recent years but still remain high, researchers reported.

Between 2015 and 2020, the incidence of CKD among those with diabetes dropped by an estimated 17.6 cases per 1,000 person-years, Katherine R. Tuttle, MD, of Providence Health in Spokane, Washington, and colleagues wrote in a New England Journal of Medicine correspondence. Read the full story in MedPage Today.

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Despite recommendations, statin use ‘not ubiquitous’ in CKD with ASCVD

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Overall statin use among adults with chronic kidney disease is high, yet there have been only modest increases in the use of high‐intensity statins, ezetimibe and PCSK9 inhibitors, data from a prospective 2‐year study show.

Both the 2013 Kidney Disease: Improving Global Outcomes (KDIGO) and 2018 American College of Cardiology/American Heart Association cholesterol guidelines recommend at least statin therapy for adults with non‐dialysis-dependent chronic kidney disease (CKD) and atherosclerotic CVD, as CKD is a major risk factor for disease progression, Robert S. Rosenson, MD, director of metabolism and lipids for the Mount Sinai Health System and professor of medicine in cardiology at the Icahn School of Medicine at Mount Sinai, and colleagues wrote. Read the full story in Healio.

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Premature aging may play a role in the progression of CKD

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A better understanding of chronic kidney disease may be found in the study of aging, according to a presenter at the International Conference on Dialysis.

As Healio has previously reported, aging increases the prevalence of some diseases, including chronic kidney disease. Moreover, the loss of kidney function may result in a disconnect between chronological and biological age, according to a presentation.
Read the full story in Healio.

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Report cites health inequity, disconnect with primary care as barriers for treating CKD

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A new report from the Milken Institute recommends that health officials prioritize identification of the root causes of health inequity that contribute to kidney disease in efforts to slow down its occurrence.

“Tackling this public health issue requires a whole-of-society effort, and in this report, we call on policymakers (federal, state and local), government agencies, health care administrators, health care providers, allied health professionals, payers, members of the community and community-based organizations (CBOs) to assume leadership and supporting roles and to collaborate with intention and urgency across public health, health delivery and nontraditional health sectors,” Sarah Wells Kocsis, MBA, director of the Milken Institute’s Center for Public Health and colleagues wrote in the report.
Read the full story from Healio.

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Kidney stones, CKD connection unclear, but clinicians collaborate on treatment

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It did not take long for nephrologist and kidney stone specialist David S. Goldfarb, MD, FASN, to realize that the buildup of pain radiating from the right side of his abdomen was from a kidney stone that had begun its downward migration.

And he came to the realization based on his experience with kidney stones – this was his second one – that the escalating pain meant he did not have the 30 minutes it would take by car to get to his favored hospital and employer, New York University’s Langone Health, for treatment. He told the driver – his wife – to divert to closer-by Columbia-Presbyterian Hospital. Read more in Healio.

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Patients who receive CKD education are likely to choose home dialysis at initiation

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Compared with patients who did not receive chronic kidney disease education, those who did were more likely to choose home dialysis and a permanent vascular access at initiation.

“Treatment options for kidney failure are complex, and the majority of patients who develop kidney failure lack important information about treatment options and are not prepared to make informed decisions about their care,” Katherine Mckeon, MSPH, from DaVita Clinical Research in Minnesota, and colleagues wrote.  Read more in Healio.

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Physical activity correlates with lower risk of cardiovascular events in patients with CKD

Photo by Arek Adeoye on Unsplash
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Higher self-reported physical activity correlated with lower risk for cardiovascular events among patients with chronic kidney disease, according to data published in the American Journal of Kidney Diseases.

“Although CKD guidelines include recommendations for minimal levels of physical activity, the recommendations are largely based on studies in the general population.
Read more in Healio.

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