Cost of diabetes care in US rises to $412.9 billion in 2022

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By Michael Monostra

The total annual cost of caring for Americans with diabetes in 2022 was an estimated $412.9 billion, and one in four total health care dollars in the U.S. went toward diabetes care, according to a report.

The American Diabetes Association published its Economic Costs of Diabetes in the U.S. in 2022 report in Diabetes Care to assess the financial burden for people living with diabetes.
Read the full article in Healio.

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Kidney Week Roundup: Cell Therapy Cuts Immunosuppressive Drug Use Post-Transplant

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— Plus: bardoxolone methyl for diabetic kidney disease and spironolactone in hemodialysis patients

By Kristen Monaco

PHILADELPHIA — Some of the latest research in the field of nephrology presented at the American Society of Nephrology’s Kidney Week included sparsentan in focal segmental glomerulosclerosis, combination treatment with an SGLT2 inhibitor and an endothelin A receptor antagonist, and a novel aldosterone synthase inhibit in chronic kidney disease. Below are a few more highlights.
Read the full story in MedPage Today.

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Researchers Create App to Predict Whether Child in Acute Liver Failure Will Need Transplant

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By Kennedy Ferruggia, Assistant Editor

Children with a score of higher than 30 on the CHALF Score scale will need an emergency transplant.

In a new study conducted by Children’s Hospital Los Angeles (CHLA)researchers have developed a Children’s Hospital Los Angeles Acute Liver Failure (CHALF) Score that will help clinicians predict whether a child in acute liver failure will need a transplant or if they could recover.

Acute liver failure is defined as a rare condition in which the liver begins to lose ability to function. Read the full article in Pharmacy Times.

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Q&A: Shaping the future of lung transplantation with technology

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By Isabella Hornick
By Lisa Anderson, PhD

In the transplantation world, technology has played a major role in advancing the way donor organs are transported and preserved.

One advancement in lung transplant preservation that recently received FDA 510(k) clearance is the BAROguard system (Paragonix Technologies), which is designed to keep lungs at optimal temperatures and inflation pressures during transport, according to a press release. Read the full story in Healio.

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One in five immunosuppressed patients lack any response after three COVID vaccine doses

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By Erich Martin

Approximately 20% of patients with solid organ transplants, rare autoimmune rheumatic diseases or lymphoid cancers fail to mount a response to three or more COVID-19 vaccine doses, according to data published in The Lancet Rheumatology.

However, the researchers additionally concluded that the proportion of patients who are non-responders decreases with sequential booster doses. Read the full article in Healio.

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Sparsentan Failed to Preserve Kidney Function Over Time in FSGS

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— However, more patients on the drug achieved partial remission of proteinuria vs irbesartan

By Kristen Monaco

PHILADELPHIA — Treatment with sparsentan (Filspari) led to no significant differences in estimated glomerular filtration rate (eGFR) slope compared with irbesartan among patients with focal segmental glomerulosclerosis (FSGS), the phase III DUPLEX trial showed.
Read the full article in MedPage Today.

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Heart Failure Podcast: Think About Heart Transplant Evaluation Like This

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By Michelle M. Kittleson, MD, PhD; James C. Fang, MD

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider.

Michelle M. Kittleson, MD, PhD: Welcome to Medscape’s InDiscussion series on heart failure. I’m your host Dr Michelle Kittleson. This is the final episode in our 12-part series, and we’re capping it off by talking about the heart transplant evaluation process. What are the most difficult decision points in the medical management of heart transplantation? Where should we focus our attention to have the greatest successes? And what do we need to know to best help our patients through the involved process? Check out the complete podcast in Medscape.

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Certain Live Vaccines Safe and Effective in Pediatric Organ Transplant Patients, Study Finds

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By Patricia Weiser, Pharm.D.

Live vaccinations may be safe and effective for protection against measles, mumps, and varicella in certain pediatric recipients who have had a solid organ transplant, according to an investigation published earlier this month in JAMA Network Open.

Historically, guidelines have recommended against using live vaccines in certain immunocompromised individuals, such as those receiving a solid organ transplant (SOT).
Read the full article in Managed Healthcare Executive.

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Male Kidney Donors Recover Kidney Function Faster than Female Counterparts

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By Abigail Brooks, MA

Data presented at ASN Kidney Week 2023 suggested male kidney donors recover greater kidney function than females after donation.

Male kidney donors may experience greater kidney function recovery than females after donation, according to findings presented at the American Society of Nephrology Kidney Week 2023.

Despite similar predonation estimated glomerular filtration rate (eGFR) between male and female participants, males showed a significantly greater eGFR recovery than females through 24-month follow-up (P = .003), highlighting a potential need for sex-specific evaluation, counseling, and monitoring among kidney donors.1 Read the complete article in HCP Live.

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