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Two Girls from New Jersey Receive Lifesaving Liver Transplants at Hassenfeld Children’s Hospital

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Team from Newly Launched Pediatric Liver Disease & Transplant Program Performed the First-Ever Pediatric Liver Transplants at Hospital Within a Week of Each Other

Surgeons at Hassenfeld Children’s Hospital at NYU Langone and the NYU Langone Transplant Institute have successfully performed the first two pediatric liver transplants at the institution. The lifesaving surgeries were conducted within a week of each other, giving hope and a new lease on life to two young girls from New Jersey.

To address the rising incidence of liver disease in children and the critical need for quality care, Hassenfeld Children’s Hospital formed the Pediatric Liver Disease and Transplant Program this April.  Read the complete press release from NYU Langone Health.

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VCU Health surgeons launch robotic living liver procurement

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Innovative surgical procedure expected to expand pool of eligible living donors

Surgeons at VCU Health Hume-Lee Transplant Center are using an innovative, less-invasive robotic liver procurement procedure to expand the pool of eligible living liver donors. As the number of people registered and waiting for a liver nears 11,000, this represents a critical breakthrough in matching patients needing an organ transplant with healthy livers.

Hume-Lee Transplant Center is the nation’s only center actively offering robotic hepatectomies – the surgical removal of portions of living donors’ livers – after becoming the third U.S. center to successfully perform this innovative surgery. Read the complete article from VCU Health.

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Researchers discover a novel pathway that minimizes liver injury during transplantation

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By University of California, Los Angeles

UCLA-led research describes the role that a protein called CEACAM1 plays in protecting the liver from injury during the transplantation process, potentially improving transplant outcomes. But the features that regulate this protective characteristic remain unknown.

In a study, published online Aug. 2 in Science Translational Medicine, a research team has identified the molecular factors at the root of this protection and shown how using molecular tools and alternative gene splicing can make CEACAM1 more protective, thus reducing organ injury and ultimately improving post-transplant outcomes. Read the full article in Medical Xpress.

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UW Medicine surgeons saved a patient with dual-organ transplant

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By Lily Ramsey, LLM

Doctors in Seattle are reporting a history-making case in which a patient received two donor organs, a liver and a heart, to prevent the extreme likelihood that her body would reject a donor heart transplanted alone. In this innovative case, the organ recipient’s own healthy liver was transplanted, domino-like, into a second patient who had advanced liver disease.

The dual-organ recipient, Adriana Rodriguez, 31, of Bellingham, Washington, has recovered well since the Jan. 14, 2023, procedures, said Dr. Shin Lin, a cardiologist at the UW Medicine Heart Institute.
Read the complete article in News Medical Life Sciences.

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Transplant May Be Reasonable for Certain CRC Patients With Liver Mets

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— OS rates could be over 80% depending on clinical predictive factors

By Mike Bassett

For a select group of patients with colorectal cancer and unresectable liver metastases, liver transplant may be a reasonable option, according to results from a prospective, nonrandomized controlled cohort study.

Overall, among 61 patients who underwent liver transplant, the median disease-free survival (DFS) was 11.8 months (95% CI 9.3-14.2), with a 5-year DFS rate of 18.3%, and the median overall survival (OS) was 60.3 months (95% CI 44.3-76.4), with a 5-year OS rate of 50.4%, reported Svein Dueland, MD, PhD, of Oslo University Hospital in Norway, and colleagues. Read the full article in MedPage Today.

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Black, Hispanic Liver Disease Patients Face Transplant Disparities, Study Says

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By Matthew Griffin

(Bloomberg) — Black and Hispanic patients with a serious liver-scarring condition are less likely to receive transplants than their White peers in the US, according to researchers arguing for greater equity in providing the life-saving procedure.

Even after improvements from 2009 to 2018, Black people hospitalized for the liver ailment, cirrhosis, were only about two-thirds as likely to get transplants as White patients, according to the analysis of a national database of hospital stays. Read more in BNN Bloomberg.

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Study sheds light on cellular interactions that lead to liver transplant survival

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A new study identifies how certain proteins in the immune system interact leading to organ rejection. The study, which involved experiments on mice and human patients, uncovered an important communication pathway between two molecules called CEACAM1 (CC1) and TIM-3, finding that the pathway plays a crucial role in controlling the body’s immune response during liver transplantation. Read the full article from UCLA Health.

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Despite narrowing the gap, racial disparities persist in liver transplantation, mortality

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By Kate Burba

Disparities in receipt of liver transplantation and mortality persisted over time among hospitalized Black and Hispanic patients with decompensated cirrhosis compared with their white counterparts, according to data inJAMA Network Open.

“There had been no characterization of disparities in receipt of inpatient procedures for cirrhosis in over a decade,” Lauren D. Nephew, MD, MSCE, assistant professor of gastroenterology and hepatology and associate vice chair of health equity at Indiana University School of Medicine, told Healio. Read the full article in Healio.

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In historic procedure, donor liver protects heart transplant

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By University of Washington School of Medicine

Doctors in Seattle are reporting a history-making case in which a patient received two donor organs, a liver and a heart, to prevent the extreme likelihood that her body would reject a donor heart transplanted alone. In this innovative case, the organ recipient’s own healthy liver was transplanted, domino-like, into a second patient who had advanced liver disease. Read the full article in Medical Xpress.

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