Low incidence of donor-specific antibodies for kidney transplant recipients with COVID-19

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Despite a significant decrease in immunosuppression, the occurrence of post-COVID-19 donor-specific antibodies among COVID-19-positive kidney transplant recipients was low, according to data published in Kidney International Reports.

“Greater severity of COVID-19 has been reported in kidney transplant recipients and is most likely due to comorbidities and immunosuppressive therapy,” Christophe Masset, MD, from the Clinic Institute of Transplantation Urology Nephrology (ITUN) at the University Hospital of Nantes in France, and colleagues wrote.  Read the full story.

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Study compares heterologous and homologous third vaccination in kidney transplant recipients

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As of February 28, 2022, coronavirus disease 2019 (COVID-19) has caused over 5.95 million deaths worldwide, with especially high rates of mortality reported among the elderly, frail, and immunocompromised.

Kidney transplant recipients are among the most at-risk individuals of COVID-19 due to the need for long-term immunosuppressive medication to avoid rejection. Their response to vaccination is also poor, and researchers continue to examine methods to achieve a better vaccine response in this population. Read more.

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THINKER-NEXT Studies the Transplant of HCV-Infected Kidneys

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The next stage of the THINKER project — THINKER-NEXT — is aiming to settle any lingering concerns that patients and centers might have about using kidneys from hepatitis C (HCV)-infected donors and transplanting them into HCV-negative recipients in need of a kidney transplant.

Armed with an $8 million grant from the National Institutes of Health, researchers at the University of Pennsylvania in Philadelphia will evaluate the long-term risks and benefits of transplanting kidneys from HCV-positive donors into HCV-negative recipients and compare outcomes with those attained following transplantation of HCV-negative kidneys into HCV-negative recipients. Read more.

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Robotic kidney transplant opens door to patients with a higher BMI

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UCHealth University of Colorado Hospital on the Anschutz Medical Campus (UCH) has become the nation’s fourth medical center – and the first west of the Mississippi – to perform a kidney transplant on a high-BMI patient using a surgical robot.

The surgery, performed by University of Colorado School of Medicine transplant surgeon Dr. Thomas Pshak on Nov. 17, was the culmination of two years of preparation, and it bodes well for those who otherwise wouldn’t be able to get kidney transplants at all.
Read more.

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Obesity may increase diabetic kidney disease risk, especially in women

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Adults with type 2 diabetes and a higher BMI may have an increased risk for diabetic kidney disease, according to study findings published in The Journal of Clinical Endocrinology Metabolism.

In findings from a generalized summary Mendelian randomization using 56 BMI-associated single nucleotide polymorphisms instrument variables, increasing BMI was linked to an increased risk for diabetic nephropathy and a lower estimated glomerular filtration rate, with the effects most pronounced among women. Read more.

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SLU Transplant Team Enrolls Participants in National Kidney Study

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Newswise — ST. LOUIS – African Americans have an increased risk of kidney failure, and new research shows that some of this risk is related to variations in a gene called apolipoprotein L1 (APOL1). It’s a risk Deryl Cunningham, a kidney transplant patient at SSM Health Saint Louis University Hospital, knows all too well.

When Cunningham was diagnosed with stage 2 kidney disease by a doctor in Terre Haute, Indiana, he assumed he had been handed a death sentence. Upon relocating to Edwardsville, Illinois, a local nephrologist mentioned rare instances that kidney disease can be reversed. From there, he began his research. Read more.

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Racial disparities in kidney transplantation access are highest among young adults

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In a retrospective study of adults initiating kidney failure treatment during 2011-2018, disparities in kidney transplantation by race were highest among patients age 22-44 years of age. Within this age group, kidney failure was treated by kidney transplantation among 10.9% of white patients but only 1.8% of Black and 4.4% of Hispanic patients.

In a retrospective study of adults initiating kidney failure treatment during 2011-2018, disparities in kidney transplantation by race were highest among patients age 22-44 years of age. Within this age group, kidney failure was treated by kidney transplantation among 10.9% of white patients but only 1.8% of Black and 4.4% of Hispanic patients. Read more.

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Kidney transplant recipients were more careful than the general population during pandemic

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During the first few waves of COVID-19, kidney transplant recipients in Norway engaged in less social interaction than the general population and strongly adhered to government advice, according to data published in Kidney Medicine.

Further, kidney transplant recipients reported feeling more concerned about infections despite living in a country with low infection rates. Read more.

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