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Kidney Transplant Recipients Have Insufficient Immunity During COVID-19 Illness

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Investigators have found evidence of reduced T cell immunity during COVID-19 illness followed by T cell recovery in kidney transplant recipients. Insufficient immunity appears to occur despite initial reduction of antirejection medications in these patients.

Most centers have empirically reduced anti-rejection immunosuppression in kidney transplant recipients with COVID-19 due to concerns that immunosuppressant use would hinder anti-COVID-19 immunity, Madhav C. Menon, MBBS, of Yale University in New Haven, Connecticut, and colleagues explained in the Journal of the American Society of Nephrology. Read the full story in Reanl & Urology News.

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The Importance of Transplant Nephrology to a Successful Kidney Transplant Program

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Introduction

Nephrologists are responsible for the care of patients with a diverse array of systemic diseases, comorbidities, and kidney issues across a variety of service locations (clinic, inpatient, dialysis unit). As the field of nephrology becomes increasingly complex, there has been a need for advanced training and subspecialization, similar to the transformation cardiology experienced with heart failure, electrophysiology, and interventional cardiology. Read the full article in the Clinical Journal of the American Society of Nephrology (CJASN).

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New modeling system identifies potential therapeutics for autosomal recessive polycystic kidney disease

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Organoids-;lab grown cells or tissues that resemble organs-;serve as a new tool for disease modeling, but researchers often have difficulty replicating the biophysical conditions in which the organs operate within the body.

This is especially true for modeling human diseases that require stimuli from cell microenvironments. Read more in News Medical Life Sciences.

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Religiosity and spirituality may positively impact the well-being of kidney transplant recipients

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1. In this scoping review, religiosity and spirituality (R/S) were positively associated with the well-being of kidney transplant recipients, primarily through increased adherence to immunosuppressant medication and coping.

2. Locus of control had a significant impact on adherence to immunosuppressive medications post-kidney transplantation.

Read more in 2 minute medicine.

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Kidney Transplant Recipients Have Insufficient Immunity During COVID-19 Illness

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Investigators have found evidence of reduced T cell immunity during COVID-19 illness followed by T cell recovery in kidney transplant recipients. Insufficient immunity appears to occur despite initial reduction of antirejection medications in these patients.

Most centers have empirically reduced anti-rejection immunosuppression in kidney transplant recipients with COVID-19 due to concerns that immunosuppressant use would hinder anti-COVID-19 immunity, Madhav C. Menon, MBBS, of Yale University in New Haven, Connecticut, and colleagues explained in the Journal of the American Society of Nephrology. Read more in Renal & Urology News.

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Innovative Clinical Trial Targets Recurrent BK Infection in Kidney Transplant Recipients

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Kidney transplant patients like Tessa Adolph, from Rockford, Illinois, face an age-old problem to protect their new kidney and bodies after transplant surgery: how to prevent infections while also safeguarding their new kidney from damage or rejection.

In Adolph’s case, the risk came from the BK virus.

At 19, she was diagnosed with Henoch-Schönlein purpura, a rare condition that causes small blood vessels in the body organs, including kidneys, to become inflamed and bleed. This transitioned into a condition called IgA nephropathy, or Berger’s disease, that over time can cause kidney scarring and eventual kidney failure, she said. Read the full article from UW School of Medicine and Public Health.


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Black Patients’ Odds of Kidney Transplant Referral May Have Improved

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Despite being markedly overrepresented among patients on dialysis, Black patients are less likely to be referred for a kidney transplant. Now, a recently implemented policy change may improve Black patients’ odds of a kidney transplant referral.

In September 2021, the American Society of Nephrology-National Kidney Foundation (ASN-NKF) Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases recommended that the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation be altered to eliminate the race variable to estimate glomerular filtration rate (GFR) in all laboratories. It also recommended more widespread use of cystatin C. Read the full article in Renal & Urology News.

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Delirium after kidney transplantation increases risk of dementia, cognitive decline

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Patients who experience delirium after a kidney transplantation are at an increased risk for dementia and cognitive decline, according to data published in the American Journal of Transplantation.

“While there have been studies of the cognitive sequelae of delirium in other surgical populations, kidney transplantation (KT) is a unique surgery in which the restoration of kidney function improves cognition on average,” Mara A. McAdams-DeMarco, PhD, an associate professor of surgery and population health at New York University Grossman School of Medicine, told Healio. Read the full story in Healio.

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