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Study finds thresholds for low oxygen leading to acute kidney injury in cardiac surgery

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By Erik Swain

Researchers identified thresholds for low oxygen delivery leading to acute kidney injury during cardiac surgery that were lower than previously reported.

“Our team has a longstanding interest in evaluating determinants of postoperative acute kidney injury using clinically informed datasets,” Donald S. Likosky, PhD, head of the Section of Health Services Research and Quality at the University of Michigan Health Department of Cardiac Surgery, told Healio. Read the full article in Healio.

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Pittsburgh native with a kidney transplant competes on ‘Survivor’: ‘I never thought that could be me’

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By Hanna Webster

Josh Wilder never expected to spend weeks surviving in the wild on national television.

He was born with Prune Belly syndrome, a rare genetic condition in which some internal organs and the abdominal muscles don’t fully develop. He frequented Pittsburgh doctor’s offices and hospitals throughout his childhood and was put on a strict, low-fat diet of healthy fruits and vegetables (a kid’s favorite) to protect his kidneys.
Read more in the Pittsburgh Post-Gazette.

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OPTN Board approves measures to improve kidney offer acceptance process

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Richmond, Va., – The Board of Directors of the Organ Procurement and Transplantation Network, at its meeting June 26, unanimously approved measures intended to improve the process kidney transplant programs use to consider available organ offers. By making better usage of offer filters, kidney offers may be made more efficiently to programs that are most likely to accept such offers for their candidates.

“Every transplant program is responsible for deciding which characteristics of donor organs are acceptable for their transplant candidates,” said Jerry McCauley, M.D., M.P.H., president of the board. Read the full article from UNOS here.

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Transplant Outcomes and Usage Patterns in Adult Recipients of Deceased Donor Kidneys with COVID-19

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The following is a summary of “Patterns in Use and Transplant Outcomes Among Adult Recipients of Kidneys From Deceased Donors With COVID-19,” published in the May 2023 issue of Nephrology by Ji et al. 

For a study, researchers aimed to determine the kidney utilization patterns and transplant outcomes in adult recipients of deceased donor kidneys with active or resolved COVID-19. This study analyzed the information from 35,851 deceased donors (71,334 kidneys) and 45,912 adult patients who underwent kidney transplantation between March 1, 2020, and March 30, 2023. Read the complete article in Physician’s Weekly.

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Men share unbreakable bond: Kidney transplant brings strangers together

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By Doug Evans

FAYETTE COUNTY, Ga. – FOX 5 brought together two local men whose lives were changed forever by a kidney transplant back in February. FOX 5 first reported on McIntosh High School athletic director Leon Hammond’s need for a donated kidney last November and U.S. Secret Service agent Alan Reeves who gave him that gift of life. It’s now three months since the transplant surgery. Read or watch the full story from Fox 5 Atlanta.

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Risk Factors for Venous Thromboembolism in Kidney Transplant Recipients Identified

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By Natasha Persaud

Certain kidney transplant recipients, such as those with anemia, have increased risks of venous thromboembolism, investigators reported at the 2023 American Transplant Congress in San Diego, California.

Investigators matched 65 recipients at their institution who experienced venous thromboembolism with 65 recipients who did not by age and year of transplantation. Median patient age at transplantation was 54 years. Read the full article in Clinical Pain Advisory.

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New Antiviral Option for CMV Prophylaxis After Kidney Transplant

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— Letermovir proved noninferior to standard of care in clinical trial

By Jeff Minerd

Letermovir (Prevymis) proved noninferior to valganciclovir (Valcyte), the standard of care, in a clinical trial of cytomegalovirus (CMV) prophylaxis in high-risk kidney transplant patients, researchers reported.

In a phase III trialopens in a new tab or window of 589 patients randomized 1:1 to receive either drug for up to 200 days post-transplant, the prevalence of CMV disease at 1 year was not significantly different in the letermovir group versus the valganciclovir group (10.4% vs 11.8%, adjusted difference -1.4%, 95% CI -6.5% to 3.8%), reported Ajit Limaye, MD, of the University of Washington Medicine in Seattle, and colleagues.
Read the full article in MedPage Today.

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Kidney Transplantation Referral May be Impeded by Dialysis Providers’ Beliefs

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By Natasha Persaud

KDIGO guidelines advise health care providers to refer patients on dialysis with past non-adherence to transplant centers for evaluation as possible kidney transplant candidates, yet not all qualified patients are referred, investigators reported at the 2023 American Transplant Congress in San Diego, California. In some cases, providers delay referral or opt not to refer based on their idiosyncratic and subjective beliefs about patients’ non-adherence.

“We believe most providers at dialysis centers and at transplant centers want all eligible patients referred for kidney transplantation,” Adam S. Wilk, PhD, and Jenny McDonnell, PhD/MPH candidate, of Emory University’s Rollins School of Public Health in Atlanta, Georgia, said in a joint statement to Renal & Urology News. Read more in Renal & Urology News.

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ESKD, Death Risks Are High After Heart Transplantation With Kidney Dysfunction

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By Natasha Persaud

Heart-alone transplant recipients with pre-existing kidney impairment have “unacceptably high” risks of progressing to end-stage kidney disease (ESKD) requiring renal replacement therapy and dying, investigators warned at the 2023 American Transplant Congress in San Diego, California.

Using the 2000-2018 Scientific Registry of Transplant Recipients, Rose Mary Attieh, MD, of the Mayo Clinic in Jacksonville, Florida, and colleagues identified 3391 first-time recipients of a heart-only transplant who had a low baseline estimated glomerular filtration rate (eGFR; in mL/min/1.73m2).
Read the full story in Renal & Urology News.

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The ultimate Father’s Day gift: Daughter donates lifesaving kidney to N.J. dad

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By Rob Jennings

Bill Hemstead expects to celebrate a Father’s Day this year unlike any other in his life.

His three adult daughters — who are scattered across the country in Wisconsin, Hawaii and Colorado — will all be joining him Sunday at their childhood home in West Milford along with Kathy, their mother and Hemstead’s wife of nearly 36 years.
Read the full story in NJ.com.

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