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AHA: Investments, improvements in research critical for equity in women’s heart health

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Clinicians and researchers must address pervasive gaps in knowledge and care delivery to reduce sex-based disparities and achieve equity in cardiology care, according to a presidential advisory from the American Heart Association.

In the advisory, the AHA presents a “roadmap” to implementing a vision for equity for women and their CV health. The statement focuses on epidemiology and prevention, awareness, access and delivery of equitable health care and providing a call to action across multiple disciplines. Read the full story in Healio.

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Cardiac transport system linked to better outcomes after heart transplantation

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A cardiac transport system for donor hearts was associated with better 1-year outcomes for recipients compared with traditional cold storage, according to new data from the GUARDIAN registry.

The analysis, presented at the International Society for Heart and Lung Transplantation Annual Meeting and Scientific Sessions, compared survival and other postoperative outcomes in heart transplant recipients who received a heart delivered with the cardiac transport system (SherpaPak cardiac transport system, Paragonix Technologies) with those whose hearts were delivered in traditional cold storage. Read more in Healio.

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Study unlocks key to improved outcomes for heart transplant recipients

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A renewed interest in intravenous ascorbic acid, also known as vitamin C, could improve long-term success outcomes for patients undergoing solid-organ transplant.

Published June 11 in the journal Circulation, the study explores a mechanism for enhancing TET2 (TET methylcytosine dioxygenase 2) enzymatic activity with high dose injections of ascorbic acid. Read the full story in Medical Xpress.

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Vital Signs: Working to better preserve hearts for transplants

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Studies have shown that hearts and other donor organs are very sensitive to the temperatures at which they are preserved during transport. Temperatures below 2 degrees Celsius have been shown to have a negative effect on outcomes for transplant patients and potentially be linked to complications related to the viability of a donor organ for transplant.
Read the full story in The Daily Progress.

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Vital Signs: Working to better preserve hearts for transplant

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Studies have shown that hearts and other donor organs are very sensitive to the temperatures at which they are preserved during transport. Temperatures below 2 degrees Celsius have been shown to have a negative effect on outcomes for transplant patients and potentially be linked to complications related to the viability of a donor organ for transplant.

Another challenge is related to the lack of data related to organ conditions during transport. With the standard method of preserving organs — packing them in ice — it is difficult to know the precise temperature at which a donated organ is being preserved during transport. Read the full article in The Daily Progress.

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Sleep apnea-related mortality continuously increased in Black men in US over past 2 decades

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A new study published in Sleep Medicine highlights an uptrend in sleep-related mortality and associated cardiovascular disease outcomes among Black men in the U.S.

“Overall, a steady increase in mortality was seen from 1999 to 2008, but the rate remained flat throughout the remainder of the study period. This pattern was observed in Black females and both genders for whites. However, Black males are the only demographic group that had a continuous increase in mortality between 1999 and 2019,”Yu-Che Lee,MD, MPH, resident physician in the department of medicine at the University of Buffalo-Catholic Health System, New York, and colleagues wrote. Read the story in Healio.

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Regular exercise yields greater CV benefit in adults with anxiety, depression

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WASHINGTON — For adults with anxiety or depression, regular exercise had nearly double the CV benefit compared with those without these diagnoses, researchers reported at the American College of Cardiology Scientific Session.

“Our findings are not meant to suggest that exercise is only good or has CV benefit in those with [anxiety and/or depression], but it does suggest that people with stress-related conditions tend to derive a greater benefit,” Hadil Zureigat, MD, postdoctoral clinical research fellow at Massachusetts General Hospital, said during an ACC press conference. “It also emphasizes stress-related neural pathways in explaining part of the CV benefit of exercise.” Read the full story in Healio.

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CareDx Reports Over 200,000 Heart Transplant Patient Results Served

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CareDx Testing Services Have Been Used in Over 30,000 Heart Transplant Patients and Over 90 Percent of Centers in the United States

SOUTH SAN FRANCISCO, Calif., April 14, 2022 (GLOBE NEWSWIRE) — CareDx, Inc. (Nasdaq: CDNA) – The Transplant Company™ focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers – today announced that it has delivered over 200,000 AlloMap® or AlloSure® results for over 30,000 heart transplant recipients.1

“We are proud to have a long-standing and trusted relationship with the heart transplant community. Since 2005, we have served half of all heart transplant patients in the U.S. with AlloMap or AlloSure, and AlloMap has the distinction of being the only FDA cleared gene-expression profiling test (GEP) for use in heart transplants, the only GEP incorporated in International Society for Heart and Lung Transplantation guidelines, and the only one covered by CMS for multimodality assessment using AlloSure donor-derived cell-free DNA,” said Reg Seeto, CEO and President of CareDx. “Importantly, we have earned this trust by conducting multi-center prospective studies that have been published in leading journals such as the New England Journal of Medicine.”
Read the complete press release on CareDx.com here.

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