Use of kidneys from COVID-positive donors has increased, not linked to worse outcomes

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By Justin Cooper

Kidneys from donors with COVID-19 history are not associated with worse transplant outcomes and are used at higher rates now than earlier in the pandemic, according to a study presented at ASN Kidney Week.

“Every possible strategy to increase the organ pool is important, including using organs from patients infected with COVID-19,” Mengmeng Ji, PhD, MS, MBBS, lead author of the study, told Healio. Read the full article in Healio.

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Liver transplantation using COVID-19 positive donors may be safe option to expand access

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By Monica Stonehill

BOSTON — Researchers reported similar patient and allograft survival 1 year after liver transplantation between COVID-19 positive and negative donors, showing potential for expanding organ access, according to data at The Liver Meeting.

“During the peak of the COVID-19 pandemic, the volume of liver transplants decreased worldwide,” Roy X. Wang, MD, of Penn Medicine, said in a related Q&A with AASLD.
Read the full story in Healio.

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COVID-19 rebounds in one in five Paxlovid users

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By Andrew Rhoades

About 20% of patients with COVID-19 experienced virologic rebound after receiving Paxlovid, according to an observational study published in Annals of Internal Medicine.

“We conducted this study to address lingering questions about Paxlovid and virologic rebound in COVID-19 treatment,” Mark Siedner, MD, MPH, an infectious disease clinician and researcher in the Division of Infectious Diseases at Massachusetts General Hospital, said in a press release. Read the full article in Healio.

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One in five immunosuppressed patients lack any response after three COVID vaccine doses

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By Erich Martin

Approximately 20% of patients with solid organ transplants, rare autoimmune rheumatic diseases or lymphoid cancers fail to mount a response to three or more COVID-19 vaccine doses, according to data published in The Lancet Rheumatology.

However, the researchers additionally concluded that the proportion of patients who are non-responders decreases with sequential booster doses. Read the full article in Healio.

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What’s the latest to know about COVID, flu vaccines as respiratory virus season begins?

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Vaccines lower the risk of severe illness, hospitalization and death.

By Mary Kekatos


As the United States heads into the cold-weather months, respiratory virus season has also arrived, with cases of influenza and COVID-19 likely to increase.

The Centers for Disease Control and Prevention (CDC) currently recommends that everyone 6 months and older stay up-to-date and get a flu vaccine and a COVID vaccine, and that it’s safe to get both at the same time. Read the full article in ABC News.

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Post-COVID-19 Thromboembolic Complications in Kidney Transplant Patients

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The following is a summary of “Thromboembolic complications after COVID-19 in kidney transplant recipients,” published in the September 2023 issue of Nephrology by Artan et al.


COVID-19 is associated with increased thromboembolic risk in the general population, and data is lacking on this risk in kidney transplant recipients. Researchers performed a retrospective study to assess the prevalence and risk factors for thrombotic complications in kidney transplant patients. Read more in Physician’s Weekly.

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Rebecca Osborn, MD, on Infectious Complications of Lung Transplant for COVID-19

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– CALI patients see encouraging 1-year survival, but MDRO infections are prevalent

By Kristin Jenkins

Among patients with COVID-19-associated lung injury (CALI), 45% develop acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. Most cannot be weaned from mechanical ventilation or extra-corporeal membrane oxygenation (ECMO), and lung transplantation remains one of the only treatment options.

But there was encouraging data from a retrospective case control cohort study.
Read the full article in MedPage Today.

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COVID Heart Injuries Traced Back to Infected Arterial Plaque, Inflammation

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— SARS-CoV-2 persistence in some vascular cells may have ties to long COVID

By Nicole Lou

Scientists found that the SARS-CoV-2 virus can directly infiltrate atherosclerotic plaques in coronary arteries and trigger an inflammatory response, providing one mechanism for how COVID-19 infection can lead to cardiovascular complications in some people.

Directly infected atherosclerotic tissue was found in both people who died with severe COVID-19 and underlying atherosclerosis and an ex vivo model of human vascular explants.
Read the complete article in MedPage Today.

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