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Post-Transplant Diabetes Can Be Predicted in Kidney Recipients

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Researchers published the study covered in this summary on Research Square and it has not yet been peer reviewed.

Key Takeaways

  • A retrospective, case-control study of kidney transplant recipients in China identified that a combination of the following parameters can predict post-transplant diabetes mellitus (PTDM) diagnosed after 45 days:
    • Family history of diabetes mellitus.
    • Standard deviation of fasting plasma glucose when values are fluctuating (day 3 to day 11 post-transplant).
    • Maximum fasting plasma glucose when values have stabilized (week 3 to week 6 post-transplant).
      Read the full story in MedScape.
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In Memoriam: Jim Gleason, Transplant Patient Advocate

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CareDx commemorates the life of James “Jim” Gleason, a selfless leader, patient advocate, heart transplant recipient and longtime President of the Transplant Recipients International Organization (TRIO), who died on August 26, 2022, after battling incurable pancreatic cancer. Jim spent the last few days of his life the same way he lived his life, by being a friend and patient advocate, while also working tirelessly to ensure that his organization’s important work for the transplant community would remain unabated. Meanwhile, he remained accessible to his inner circle of family, friends, industry partners, patients, and donor families. Read more at CareDx.com.

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Risks for heart disease, disability, death higher with younger age at diabetes diagnosis

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The risk for heart disease, stroke, disability and mortality among adults with diabetes is higher for those diagnosed at age 50 to 59 years than those diagnosed at age 70 years or older, according to study findings.

In an analysis of data from adults aged 50 years and older participating in the Health and Retirement Study in the U.S., adults who reported they were diagnosed with diabetes at age 50 to 59 years had an increased risk for heart disease, stroke, disability, cognitive impairment and mortality compared with matched controls without diabetes, whereas adults diagnosed at age 70 years or older had a higher risk for only mortality compared with controls. Data did not distinguish between type 1 and type 2 diabetes.
Read the full story in Healio.

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Speed Bumps Are Inevitable on the Post-transplant Journey

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Columnist Sam Kirton is quick to respond to some concerning symptoms

While working on today’s column, I considered writing about my birthday on Oct. 4. Then, a topic came to me quite unexpectedly.

On Monday, Sept. 26, I had to go to the hospital. Since the pandemic began, I’ve been careful to avoid large crowds in enclosed spaces and to always wear a mask indoors. So I was quite surprised to learn I had pneumonia — a significant complication for a post-lung transplant patient. Read more in Pulmonary Fibrosis News.

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The Search Is On for Another Xeno Heart Transplant Recipient

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— Transplant surgeons discuss testing the concept in more humans


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NATIONAL HARBOR, Md. — Playing by the strict rules of the FDA, xenotransplant researchers are itching to apply the lessons learned from this year’s historic case of cardiac surgery in their quest to move the transplant field forward amid a strained supply of donor organs.

In the landmark case, the first person to undergo a pig heart xenotransplant, David Bennett, age 57, had been denied a traditional human heart transplant from several programs before he ultimately agreed to the experimental surgery. The FDA green-lit the xenotransplant, and Bennett was kept alive for 60 days before succumbing to graft failure and sudden diastolic failure without evidence of traditional allograft rejection.
Read the full story in MedPage Today.

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Young Man Becomes First in World to Be Cured of FSGS With New Treatment

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Combined stem cell transplant and kidney transplant prove a winning combination against autoimmune FSGS

Imagine spending a good share of your childhood hooked up to a machine. While your friends are traveling on a bus to a school game or hanging out at the mall, you are at home or at a dialysis center tethered by cords, every day for at least three hours. A lot of kids would give up trying to keep up with life. Not 21-year-old Traejen Kingston. 
Read the full story from Stanford Children’s Health.

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FDA: Evusheld may lack efficacy against upcoming COVID-19 subvariants

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Evusheld demonstrates reduced protection against the omicron subvariant BA.4.6, resulting in an increased risk for infection in those exposed to that COVID-19 strain, according to an updated FDA fact sheet.

In the revised fact sheet, the FDA warned that providers should be aware of an increased risk for developing COVID-19 when exposed to certain COVID-19 variants that are not neutralized by tixagevimab packaged with cilgavimab (Evusheld, AstraZeneca).
Read the full story in Healio.

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Dialysis providers assess damage from Hurricane Ian

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Dialysis providers deployed disaster response teams this past week along the coast of Florida to assess the damage from Hurricane Ian while watching its path into Georgia and the Carolinas.

“Hurricane Ian impacted multiple U.S. Renal Care dialysis clinics along the west coast of Florida from Tampa to Naples, leaving many clinics without power, water, internet or phone access,” Mary Dittrich, MD, chief medical officer of U.S. Renal Care, told Healio. 
Read the full story from Healio.

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UNOS to Revamp Heart Allocation Rules to Rein in Transplant Waitlist Tricks

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— It may be goodbye to priority tiers, hello to points-based ranking system in coming years

NATIONAL HARBOR, Md. — Four years after a major revision of the U.S. heart transplant allocation rules, deliberations are again underway on how to curb gaming of the United Network for Organ Sharing (UNOS) system.

The recent explosion in Status 2 transplant candidates with advanced heart failure would improbably suggest that “suddenly the entire country has sicker patients,” said Shelley Hall, MD, chief of transplant cardiology at Baylor Scott & White Health in Dallas and chair of the cardiac committee for UNOS. Read more in MedPage Today.

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Age at Diabetes Onset Matters for Death, Comorbidity Risks

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— Adults diagnosed in their 50s saw far worse outcomes than those diagnosed in their 70s

Age at diabetes diagnosis was predictive of morbidity and mortality in older adults, according to data from a population-based, biennial longitudinal health interview survey.

Of 7,739 adults ages 50 and older who participated in the Health and Retirement Study survey, diabetes diagnosis at 50 to 59 years of age was significantly associated with mortality (HR 1.49, 95% CI 1.29-1.71) compared with no diabetes diagnosis, reported Judy Zhong, PhD, of NYU Grossman School of Medicine in New York City, and colleagues in JAMA Network Open. Read the full story in MedPage Today.

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