Study unlocks key to improved outcomes for heart transplant recipients

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A renewed interest in intravenous ascorbic acid, also known as vitamin C, could improve long-term success outcomes for patients undergoing solid-organ transplant.

Published June 11 in the journal Circulation, the study explores a mechanism for enhancing TET2 (TET methylcytosine dioxygenase 2) enzymatic activity with high dose injections of ascorbic acid. Read the full story in Medical Xpress.

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Donor socioeconomic status affects hematopoietic stem cell transplant outcomes

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SALT LAKE CITY — Socioeconomic disadvantage among hematopoietic stem cell transplant donors appeared associated with poorer outcomes among transplant recipients, according to study results.

The findings — presented at Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR — indicate a biologic impact of socioeconomic status on hematopoietic cells that is transferrable from HSCT donor to recipient, researchers concluded. Read more in Healio.

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Study confirms living kidney donor surgery is low risk for most patients

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The risk of major complications for people who donate a kidney via laparoscopic surgery is minimal. That is the conclusion of a 20-year Mayo Clinic study of more than 3,000 living kidney donors. Only 2.5% of patients in the study experienced major complications, and all recovered completely.

“The results of this study are extremely reassuring for individuals who are considering being living kidney donors. We found that this lifesaving surgery, when performed at experienced transplant centers, is extremely safe,” says Timucin Taner, M.D., Ph.D., chair of the Division of Transplant Surgery at Mayo Clinic’s William J. von Liebig Center for Transplantation and Clinical Regeneration in Minnesota. Dr. Taner is a co-author of the study. Read more in Medical Xpress.

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Electrolyte Abnormalities Common in Solid Organ Transplant Recipients

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Solid organ transplant recipients display a variety of electrolyte abnormalities in the early months after transplant surgery that need to be monitored, according to investigators presenting at the National Kidney Foundation’s 2022 Spring Clinical Meetings being held in Boston, Massachusetts.

Investigators examined the electronic health records of 199 recipients treated at Westchester Medical Center in Valhalla, New York during 2019 to 2021. Hypomagnesemia increased significantly 3 months after transplant, affecting 68.6% of liver, 50.9% of kidney, and 41.7% of heart transplant recipients. Read the full article in Renal & Urology News.

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Lifestyle Effects Intervention in Chronic Kidney Disease Patients

Photo by Arek Adeoye on Unsplash
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Patients with chronic kidney disease (CKD) may benefit considerably from supervised lifestyle therapies that increase physical activity and fitness. For a study, researchers conducted a randomized clinical study in 160 patients with stage 3–4 CKD to test the efficacy of a lifestyle intervention in improving cardiorespiratory fitness and exercise capacity over 36 months. Read more in Physician’s Weekly.

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Access to kidney transplantation is improving for everyone, but more work remains to be done

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Organ donation and transplantation are saving more lives in the United States than ever before, thanks to concerted work by stakeholders from across the country: donor families, organ procurement organizations, transplant centers, the Organ Procurement Transplant Network (OPTN), the hundreds of volunteers who serve on OPTN committees, and others.

I have witnessed this remarkable achievement firsthand as a transplant physician caring for people with kidney disease. I also witness the plight of people with end-stage kidney disease who languish on transplant wait lists, a situation that is compounded by the kinds of disparities seen in other aspects of health care. Read more in STAT News.

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CareDx Congratulates Board Member Dr. Hannah Valantine on ISHLT Lifetime Achievement Award

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SOUTH SAN FRANCISCO, Calif., April 28, 2022 (GLOBE NEWSWIRE) — CareDx, Inc. (Nasdaq: CDNA) – The Transplant Company™ focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers – today announced that Board member Hannah Valantine MD, a recognized leader in driving heart transplantation innovations and health equity, has received the 2022 Lifetime Achievement Award from the International Society for Heart and Lung Transplantation (ISHLT). Read the full press release on CareDx.com here.

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CareDx Extends Artificial Intelligence Leadership to Heart Transplantation

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New Addition to CareDx HeartCare Multimodality Portfolio Can Enable More Precise, Personalized Patient Care

SOUTH SAN FRANCISCO, Calif., April 28, 2022 (GLOBE NEWSWIRE) — CareDx, Inc. (Nasdaq: CDNA) – The Transplant Company™ focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers, today announced that through its ongoing partnership with OrganX, a non-profit health organization focused on cutting-edge digital health solutions, it plans to expand its HeartCare multimodality portfolio with a new artificial intelligence (AI) prognostic for cardiac allograft vasculopathy (CAV).
Read the complete press release on CareDx.com.

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