By Erich Martin
Approximately 20% of patients with solid organ transplants, rare autoimmune rheumatic diseases or lymphoid cancers fail to mount a response to three or more COVID-19 vaccine doses, according to data published in The Lancet Rheumatology.
However, the researchers additionally concluded that the proportion of patients who are non-responders decreases with sequential booster doses. Read the full article in Healio.
By Kristen Monaco
PHILADELPHIA — Treatment with sparsentan (Filspari) led to no significant differences in estimated glomerular filtration rate (eGFR) slope compared with irbesartan among patients with focal segmental glomerulosclerosis (FSGS), the phase III DUPLEX trial showed.
Read the full article in MedPage Today.
By Michelle M. Kittleson, MD, PhD; James C. Fang, MD
This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider.
Michelle M. Kittleson, MD, PhD: Welcome to Medscape’s InDiscussion series on heart failure. I’m your host Dr Michelle Kittleson. This is the final episode in our 12-part series, and we’re capping it off by talking about the heart transplant evaluation process. What are the most difficult decision points in the medical management of heart transplantation? Where should we focus our attention to have the greatest successes? And what do we need to know to best help our patients through the involved process? Check out the complete podcast in Medscape.
By Anumita Kaur
Davey Bauer’s lungs needed to go.
A double lung transplant was the only remedy for the 34-year-old, who spent years vaping, caught influenza and ended up in the hospital. But before his body could withstand the procedure, he needed time to recover without his infection-ravaged lungs.
Read the full story in The Washington Post.
By Patricia Weiser, Pharm.D.
Live vaccinations may be safe and effective for protection against measles, mumps, and varicella in certain pediatric recipients who have had a solid organ transplant, according to an investigation published earlier this month in JAMA Network Open.
Historically, guidelines have recommended against using live vaccines in certain immunocompromised individuals, such as those receiving a solid organ transplant (SOT).
Read the full article in Managed Healthcare Executive.
By Abigail Brooks, MA
Data presented at ASN Kidney Week 2023 suggested male kidney donors recover greater kidney function than females after donation.
Male kidney donors may experience greater kidney function recovery than females after donation, according to findings presented at the American Society of Nephrology Kidney Week 2023.
Despite similar predonation estimated glomerular filtration rate (eGFR) between male and female participants, males showed a significantly greater eGFR recovery than females through 24-month follow-up (P = .003), highlighting a potential need for sex-specific evaluation, counseling, and monitoring among kidney donors.1 Read the complete article in HCP Live.
By Kim Clarke
Joan and Janice Ottenbacher were always close as sisters. A lifesaving operation at University Hospital in 1964 made their bond extraordinary.
The 15-year-old identical twins were patients in the first human organ transplant in Michigan when Joan donated her kidney to Janice. Read the full story in The University Record.
By Abigail Brooks, MA
EnAKT LKD was conducted across 26 CKD programs in Ontario Canada, offering a multi-component intervention designed to target several barriers thought to prevent kidney transplantation and living donation – however, results showed no significant difference between the intervention and usual care groups.
Results from the Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) trial showed evidence of intervention uptake but no difference in steps completed toward kidney transplantation between the intervention and usual-care groups.
Read the full article in HCP Live.
By Dr. Priyom Bose, Ph.D.
Biomanufacturing of organs/tissues in vitro has been driven by two needs, i.e., organ transplantation and accurate tissue models. Bioprinting, also known as three-dimensional (3D) printing, is a technique used to develop many tissues/organs, such as the liver, skin, and heart. This technique is associated with printing structures using biomaterials, viable cells, and biomolecules. The creation of bioartificial organs has opened new avenues for future organ transplantation programs. Read the full article in News Medical Life Sciences.
By Victoria Socha
The optimal treatment for patients with end-stage kidney disease (ESKD) is living donor kidney transplantation, which offers improved health outcomes. Deprived neighborhoods are defined as those with low socioeconomic status, limited social cohesion, and reduced access to health care. According to Byoungjum Kim and colleagues, there are few data available on the role of neighborhood deprivation in assess to living donor kidney transplantation. Read the full article in DocWire News.