Liver Preserved for 3 Days With Machine Perfusion Successfully Transplanted

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— Patient healthy and leading normal life at 1 year

A patient who underwent transplant with a liver that was preserved for 3 days outside of the body using warm machine perfusion was healthy and leading a normal life at 1 year, according to researchers from Switzerland.

The recipient experienced only minimal graft injury with normal bilirubin levels and a small release of liver enzymes within the first week after receiving the graft via ex situ normothermic preservation (peak alanine transaminase [ALT] 138 UL-1 and peak aspartate aminotransferase [AST] 309 UL-1), reported Pierre-Alain Clavien, MD, of University Hospital Zurich, and colleagues. Read more in MedPage Today.

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Transplant society president calls for more collaborative efforts to increase organ supply

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The transplant community, HHS and procurement organizations need to work collaboratively to increase the organ supply for transplantation in the United States, according to remarks made at the American Transplant Congress.

“We need more than symbolic gestures from our elected officials if we are going to meet the crisis of end-stage organ failure that kills patients at a rate of 17 per day [on the waitlist] in the U.S.,” John Gill, MD, outgoing president of the American Society of Transplantation (AST), said during his address. Read more in Healio here.

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Transplant Journey – Music Playlist

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We recently put out a call to the transplant community for recommendations of songs that have been impactful during your transplant journey. As always, you didn’t disappoint! We heard from folks across the country who shared songs and some brief descriptions of how they helped them through some time times. Check out their recommendations and see the complete playlist here.

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Doctors Take Out Patient’s Damaged Liver, Transplant It Back After Treating It

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Doctors in Switzerland have successfully removed a cancer patient’s damaged liver before transplanting it back into his body after having treated the organ in a machine for three days.

The multidisciplinary Liver4Life team at the University Hospital Zurich (USZ) has claimed that the procedure is the first of its kind in the world and they credited their in-house perfusion machine with making the feat possible. Read the full story in Newsweek here.

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Kidney, heart transplant ‘years ahead of’ LT in development, implementation of biomarkers

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Although the development and use of biomarkers in liver transplantation has progressed in recent years, challenges and limitations remain, according to presenters at the American Transplant Congress 2022.

Thomas D. Schiano, MD, professor of medicine and liver diseases at Mount Sinai in New York, told attendees that among transplant patients, biomarkers should monitor short- and long-term graft function, predict acute and chronic disease development, assess donor organ quality or monitor response to therapeutic intervention. Further, biomarkers should have external validation. Read the full article in Healio.

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World’s first: Doctors successfully transplant human liver treated in a machine

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Organ transplantation is a very complicated medical procedure. The organ has to be compatible with the recipient, and the process also involves moving a live organ from donor person to recipient and maintaining the organ in working order until the surgery.

The traditional method of moving transplant organs involves storing them at a very low temperature. However, this process has a time limit and may damage organ tissues.
Read more in Medical News Today.

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Is Diabetes a Risk Factor for Long COVID? Possibly.

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— Mixed results in seven-study scoping review

The jury is still out as to whether diabetes is a risk factor for post-acute sequelae of COVID-19 (PASC), a researcher reported.

In a scoping review of seven studies, three (43%) concluded that diabetes was indeed a “potent” risk factor for developing long COVID following infection, according to Jessica L. Harding, PhD, of Emory University School of Medicine in Atlanta.
Read more in MedPage Today.

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HBCU Medical Schools to Tackle Organ Transplant Disparities

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A coalition including the four medical schools at the nation’s historically Black colleges and universities has announced a new initiative aimed at increasing the number of Black Americans registered as organ donors and combating disparities among transplant recipients.

A new initiative aimed at increasing the number of Black Americans registered as organ donors and combating disparities among transplant recipients was announced Thursday by a coalition that includes the four medical schools at the nation’s historically Black colleges and universities. Read more in U.S. News & World Report.

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