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Pumpkin Spice Pepper Hummus: The Perfect Thanksgiving Appetizer

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Get ready to delight your guests this Thanksgiving with a unique and flavorful appetizer that captures the essence of the season. Pumpkin Spice Pepper Hummus is a vibrant twist on classic hummus, blending the warm spices of autumn with the rich and creamy texture of hummus. Perfect for any holiday gathering, this appetizer is a delicious combination of pumpkin, roasted red peppers, and a dash of warming spices. It’s a delightful prelude to your Thanksgiving feast, offering a tantalizing taste of the fall season in every bite.
Get the recipe on CareDx.com.

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COVID-19 rebounds in one in five Paxlovid users

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By Andrew Rhoades

About 20% of patients with COVID-19 experienced virologic rebound after receiving Paxlovid, according to an observational study published in Annals of Internal Medicine.

“We conducted this study to address lingering questions about Paxlovid and virologic rebound in COVID-19 treatment,” Mark Siedner, MD, MPH, an infectious disease clinician and researcher in the Division of Infectious Diseases at Massachusetts General Hospital, said in a press release. Read the full article in Healio.

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Response to treatment for AKI improved 90-day survival in patients waitlisted for LT

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By Kate Burba

BOSTON — Response to treatment for acute kidney injury correlated with improved 90-day survival and shorter lengths of hospital stay among patients with cirrhosis waitlisted for liver transplant, according to data at The Liver Meeting.

“[Acute kidney injury] in cirrhosis occurs commonly in hospitalized patients with cirrhosis and leads to worse outcomes,” Xing Li, MD, MBA, a third-year gastroenterology fellow at Massachusetts General Hospital, told Healio. Read the full article in Healio.

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‘Significant differences’ reported by race, ethnicity in transplant rates for MASH-HCC

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By Kate Burba

BOSTON — Hispanic and Asian patients with metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma were less likely to undergo liver transplantation compared with other races and ethnicities, data showed.

“MASH-HCC rates are much higher in our Hispanic patients and have surpassed hepatitis C-related HCC in 2019,” David W. Victor, MD, associate professor of clinical medicine at Houston Methodist Hospital, said at The Liver Meeting. Read the full article in Healio.

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Mid-Stage Win for Novel IgA Nephropathy Drug

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— APRIL-neutralizing antibody sibeprenlimab reduced proteinuria and stabilized eGFR

By Kristen Monaco

PHILADELPHIA — An investigational humanized IgG2 monoclonal antibody reduced proteinuria in adults with immunoglobulin A (IgA) nephropathy at high risk for disease progression despite standard treatments, a randomized phase II trial found.

In a dose-dependant manner, intravenous sibeprenlimab led to significantly greater decreases in 24-hour urinary protein-to-creatinine ratio at 12 months compared with placebo, with geometric mean ratio reductions ranging from 47.2% to 62% versus 20%, respectively (P<0.001), meeting the trial’s primary endpoint, reported Mohit Mathur, MD, of drugmaker Visterra in Waltham, Massachusetts. Read the full article in MedPage Today.

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Mayo Clinic performs first ever robot-assisted kidney transplant

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By Cathy Wurzer and Aleesa Kuznetsov


It is a full circle moment for Mayo Clinic. Next week will be the 60th anniversary of the clinics first kidney transplant from a living donor.

Now 60 years later, the clinic has performed it’s first robot-assisted kidney transplant.

On Oct. 4, a woman in her 60s received a kidney from her daughter. Dr. Timucin Taner is the division chair of Transplant Surgery at Mayo Clinic. Read the full article in MPR News.

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Cost of diabetes care in US rises to $412.9 billion in 2022

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By Michael Monostra

The total annual cost of caring for Americans with diabetes in 2022 was an estimated $412.9 billion, and one in four total health care dollars in the U.S. went toward diabetes care, according to a report.

The American Diabetes Association published its Economic Costs of Diabetes in the U.S. in 2022 report in Diabetes Care to assess the financial burden for people living with diabetes.
Read the full article in Healio.

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Kidney Week Roundup: Cell Therapy Cuts Immunosuppressive Drug Use Post-Transplant

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— Plus: bardoxolone methyl for diabetic kidney disease and spironolactone in hemodialysis patients

By Kristen Monaco

PHILADELPHIA — Some of the latest research in the field of nephrology presented at the American Society of Nephrology’s Kidney Week included sparsentan in focal segmental glomerulosclerosis, combination treatment with an SGLT2 inhibitor and an endothelin A receptor antagonist, and a novel aldosterone synthase inhibit in chronic kidney disease. Below are a few more highlights.
Read the full story in MedPage Today.

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Researchers Create App to Predict Whether Child in Acute Liver Failure Will Need Transplant

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By Kennedy Ferruggia, Assistant Editor

Children with a score of higher than 30 on the CHALF Score scale will need an emergency transplant.

In a new study conducted by Children’s Hospital Los Angeles (CHLA), researchers have developed a Children’s Hospital Los Angeles Acute Liver Failure (CHALF) Score that will help clinicians predict whether a child in acute liver failure will need a transplant or if they could recover.

Acute liver failure is defined as a rare condition in which the liver begins to lose ability to function. Read the full article in Pharmacy Times.

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Q&A: Shaping the future of lung transplantation with technology

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By Isabella Hornick
By Lisa Anderson, PhD

In the transplantation world, technology has played a major role in advancing the way donor organs are transported and preserved.

One advancement in lung transplant preservation that recently received FDA 510(k) clearance is the BAROguard system (Paragonix Technologies), which is designed to keep lungs at optimal temperatures and inflation pressures during transport, according to a press release. Read the full story in Healio.

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