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U.S. on pace to top 40,000 transplants in a single year for first time

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“In just the first half of 2021, 21,061 organ transplants have been performed in the U.S. according to data from United Network for Organ Sharing (UNOS), which serves as the Organ Procurement and Transplantation Network under federal contract.

Organ donation from deceased donors is up 15% over last year. There were 900 more deceased donors — people who provided one or more organs to save and enhance the lives of others — between January 1 and June 30 of 2021 than there were during the same period in 2020. The drop in donors caused by the pandemic beginning in the middle of March last year was offset enough by high numbers early in the year that there were still 242 more donors in the first half of 2020 than in the first half of 2019.

Organ transplants from deceased donors are also up — by 11%. A total of 17,821 deceased donor transplants were performed in the U.S. in the first half of 2021 compared to 15,933 in the first six months of last year. 2020 marked the 10th consecutive record breaking year for organ donation from deceased donors and the 8th in a row for deceased donor transplants.”

Read more, here.

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The Science Supporting the U.S. Case for COVID Boosters

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“U.S. health officials laid out the scientific rationale for a third dose of the COVID-19 mRNA vaccines for all U.S. adults on Wednesday, relying on published and unpublished CDC data, as well as a preprint study.

Overall, they said that there is evidence that vaccine effectiveness against infection — both symptomatic and asymptomatic — has been decreasing over time, but that protection against severe disease, hospitalization, and death remains relatively high.

In anticipation of further waning of immunity amid the ongoing Delta variant-fueled surge — which is posing additional challenges — pulling the trigger on booster shots could help the U.S. stay ahead of the virus, they said.”

Read more, here.

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Kidney Transplant Outcomes Improved Over Past Quarter-Century

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“Things have looked up for U.S. kidney transplant recipients over the past few decades, according to a review article.

In adult kidney transplant recipients, the total number of transplants from living and deceased donors in the U.S. jumped from 45,008 in 1996-1999 up to 76,885 in 2016-2019, reported Sundaram Hariharan, MD, of the University of Pittsburgh School of Medicine, and colleagues.

This uptick was largely driven by a rise in the number of transplants from deceased kidney donors, from 29,823 in 1996 to 53,139 in 2019, they stated in the New England Journal of Medicine.”

Read more, here.

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Equity means providing a transplant for every single patient that needs one

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“Recently, I joined UNOS President-Elect Jerry McCauley, M.D. at a meeting organized by the National Academies of Sciences, Engineering and Medicine (NASEM) focused on equity. We were honored to share UNOS’ work in this space and lend our voices to this vital national discussion – a discussion we look forward to continuing.

UNOS is acutely attuned to issues of equity. As the mission-driven non-profit serving as the nation’s transplant system, we work with our community partners to ensure equitable policies and outcomes in multiple ways, including:”

Read the full article, here.

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Pfizer-BioNTech COVID-19 vaccine becomes first to win FDA’s full approval, paving way for boosters, mandates

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“Eight months after authorizing the Pfizer-BioNTech COVID-19 vaccine for emergency use in the USA, the Food and Drug Administration issued its full stamp of approval.

Now that the companies’ detailed, so-called biologics license application has been granted, it’s likely that vaccination will be required by many companies, schools and other entities. 

Monday, President Joe Biden called on companies, nonprofit groups, government agencies and schools to “step up vaccine requirements that will reach millions more people.” 

Vaccinations allowed people in this country to stop worrying about diseases such as smallpox, polio, measles, mumps and rubella, he said, and vaccines can help do the same for COVID-19.”

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The Beginner’s Guide to Starting a Plant-Based Diet (When You Have Kidney Disease)

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Why start a plant-based diet?

“A plant-based diet includes eating more plant foods like whole grains, fruits, vegetables, nuts, legumes (beans, peas, and lentils), and healthy plant oils (such as olive or canola) and less animal foods like dairy, eggs, fish, and meat. Growing evidence shows that plant-based diets may help prevent health problems like heart disease and further kidney damage in people with kidney disease. Some studies say that people living with kidney disease who followed a plant-based diet lived longer than those whose diets were more animal-based. However, starting a plant-based diet does not mean that you need to become a vegetarian and cut all sources of animal protein from your diet. One study has shown that swapping out animal protein with plant protein at two out of three meals per day may be enough to provide health benefits of a plant-based diet in patients with chronic kidney disease.”

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USC Stem Cell scientists make big progress in building mini-kidneys

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“A team of scientists at the Keck School of Medicine of USC has created what could be a key building block for assembling a synthetic kidney. In a new study in Nature Communications, Zhongwei Li and his colleagues describe how they can generate rudimentary kidney structures, known as organoids, that resemble the collecting duct system that helps maintain the body’s fluid and pH balance by concentrating and transporting urine.

“Our progress in creating new types of kidney organoids provides powerful tools for not only understanding development and disease, but also finding new treatments and regenerative approaches for patients,” said Li, the study’s corresponding author and an assistant professor of medicine, and of stem cell biology and regenerative medicine.”

Learn more, here.

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Despite COVID-19, Cedars-Sinai Hits New Transplant Record

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“This spring, anesthesiologist Jennifer Cutler, MD, was looking forward to a weekend relaxing with her husband and two teenaged children when she got the call – she was urgently needed to oversee anesthesiology for not one, but two, liver transplants at Cedars-Sinai.

Cutler, who enjoys spending her weekends going on long runs, catching up on her to-do list and savoring family dinners, dropped everything to come in to work. She wasn’t “on call,” per se, but Cutler said that when she and her fellow anesthesiologists are needed for a transplant surgery, they go.

“Even when we’re not on call, we just all pitch in and get the cases done,” Cutler said. “We have always had an attitude of teamwork.”

That weekend, surgeons from the Cedars-Sinai Comprehensive Transplant Center and Smidt Heart Institute performed a whopping 11 transplant surgeries in a single weekend. They performed one heart transplant, two liver transplants, two dual kidney/pancreas transplants, and six kidney transplants (including one pediatric kidney transplant).”

Read more, here.

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Could Nixing Race-Adjustments for eGFR Harm Black Cancer Patients?

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“Removing race from estimated glomerular filtration rate (eGFR) equations would result in fewer Black patients being eligible for certain anticancer drugs, researchers have demonstrated.

Their analysis showed that for Black patients, removing race from the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation reduced median eGFR from 103 mL/min to 89 mL/min. In addition, removing the race factor doubled the percentage of black patients with an eGFR under 60 mL/min — a clinically relevant cut-off below which many drugs have recommended changes to dosage and eligibility, reported Thomas D. Nolin, PharmD, PhD, of the University of Pittsburgh School of Pharmacy, and colleagues.”

Learn more here.

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Weight Cycling Linked With Poor Outcomes in Chronic Kidney Disease

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“Large fluctuations in body mass index (BMI) over time — otherwise known as weight cycling — were associated with poorer outcomes in patients with chronic kidney disease (CKD), according to an observational study.

In 84,636 predialysis patients with CKD followed for a median of 4 years, those in the highest quartile of BMI variability had an increased risk for all-cause mortality compared with the lowest quartile (HR 1.66, 95% CI 1.53-1.81, P<0.001), reported Dong Ki Kim, MD, PhD, of Seoul National University College of Medicine in South Korea, and colleagues.”

Read more, here.

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