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BP Control Beneficial for Liver Transplant Recipients

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— Patients who kept their blood pressure under 140/90 mm Hg had better kidney function at 1 year

WASHINGTON — Controlling blood pressure (BP) in liver transplant recipients led to better renal function at 1 year, post hoc data from a randomized trial suggested.

Recipients taking medication to control their BP had an estimated glomerular filtration rate (eGFR) that was 12.2 mL/min higher at 1 year when they were able to keep their BP below 140/90 mm Hg after liver transplant, reported Elizabeth Cabrera, MD, of Northwestern Memorial Hospital in Chicago. Read more in MedPage Today.

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Heart Transplant Outcomes Similar With COVID-19–Positive Donors

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Patients who receive hearts from COVID-19–positive donors will likely have short-term outcomes similar to those who receive hearts from COVID-19–negative donors, two retrospective analyses suggest.

COVID-19 rarely causes cardiac injury among young, healthy people; however, endothelial dysfunction and subcellular derangements might have longer-term consequences for a mild or subclinical infection in the transplanted organ, according to Clancy Mullan, MD, and colleagues at the Yale School of Medicine in New Haven, Connecticut. 
Read the full story in Medscape.

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Low Carb Diet Boosts Weight Loss for Liver Transplant Recipients With Obesity

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— LCD also positively impacted patients’ metabophenotype

Liver transplant recipients benefited from a low carbohydrate diet (LCD), achieving weight loss and an improved metabolic phenotype profile, according to a randomized trial.

In an interim analysis involving 27 patients, those who followed an LCD had a significantly higher mean weight loss of nearly 8 kg (about 17 lbs) over 6 months, compared to those on a low calorie restricted diet (CRD), who did not experience any significant weight loss (P=0.01), reported Mohammad Siddiqui, DO, of Virginia Commonwealth University in Richmond. Read more in MedPage Today.

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The Importance of Transplant Nephrology to a Successful Kidney Transplant Program

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Introduction

Nephrologists are responsible for the care of patients with a diverse array of systemic diseases, comorbidities, and kidney issues across a variety of service locations (clinic, inpatient, dialysis unit). As the field of nephrology becomes increasingly complex, there has been a need for advanced training and subspecialization, similar to the transformation cardiology experienced with heart failure, electrophysiology, and interventional cardiology. Read the full article in the Clinical Journal of the American Society of Nephrology (CJASN).

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New modeling system identifies potential therapeutics for autosomal recessive polycystic kidney disease

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Organoids-;lab grown cells or tissues that resemble organs-;serve as a new tool for disease modeling, but researchers often have difficulty replicating the biophysical conditions in which the organs operate within the body.

This is especially true for modeling human diseases that require stimuli from cell microenvironments. Read more in News Medical Life Sciences.

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Did My Strong COVID Vax Reaction Give Me Better Immunity?

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— As people roll up their sleeves for another booster, here’s where the science stands

Is a strong reaction to the COVID-19 vaccine a sign of a more robust immune response that ultimately brings better protection against infection, hospitalization, and death?

Many are asking that question as they roll up their sleeves for yet another booster.

Science doesn’t have a definitive answer, as the literature is generally mixed — although two papers in the JAMA network of journals suggest that experiencing more side effects does correlate with higher levels of anti-spike antibodies. Read more in MedPage Today.

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First pig-to-human cardiac transplant alters heart’s electrical signals

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A recent study to be presented at the American Heart Association (AHA) Scientific Sessions 2022* revealed unexpected changes in the electrical conduction system of the first genetically-modified porcine-to-human heart xenotransplant.

Xenotransplantation is the procedure of transplantation/implantation into a human of organs from non-human animal sources. Read more in News Medical Life Sciences.

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Religiosity and spirituality may positively impact the well-being of kidney transplant recipients

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1. In this scoping review, religiosity and spirituality (R/S) were positively associated with the well-being of kidney transplant recipients, primarily through increased adherence to immunosuppressant medication and coping.

2. Locus of control had a significant impact on adherence to immunosuppressive medications post-kidney transplantation.

Read more in 2 minute medicine.

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