Página 148 – Allocare

agosto 4, 2021agosto 4, 2021

Pharma CEO Faces Personal Fight for a New Breed of Organ Donors

“A doctor at Children’s National Medical Center in Washington, D.C., had just told Rothblatt and her wife, Bina, that the couple’s youngest daughter, 9-year-old Jenesis, had a rare medical condition that likely gave her three years to live. The arteries between Jenesis’s heart and lungs had narrowed, choking off oxygen and placing an unsustainable burden on her heart as it struggled to send blood through her thinning blood vessels, like trying to push water through a hose with a kink in it. The condition, known as pulmonary arterial hypertension, was progressive, and there were no approved treatments, short of a lung transplant—almost unheard-of in children.”

Getting the COVID-19 Vaccine, What Kidney Patients Need to Know

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Most doctors agree that the benefits of the COVID-19 vaccine for people with kidney disease at any stage, including those on dialysis and those with a kidney transplant, are much greater than the risk of serious complications from the virus than from the vaccine.

Dialysis patients who contract COVID-19 are at extremely high risk of short-term mortality, possibly higher than 20 percent.

The National Kidney Foundation, American Society of Nephrology, and American Society of Transplantation all recommend that people with kidney disease or kidney transplant be vaccinated for COVID-19.

Vaccines are one of the most effective tools to protect your health and prevent disease. Vaccines work with your body’s natural defenses so your body will be ready to fight a virus if you are exposed (also called immunity).”

Immunocompromised to unvaccinated: You’re still a community

3 Clark County women hope unvaccinated people stop and consider those who are at high risk of serious complications from COVID-19

“As people across the United States continue to flout the COVID-19 vaccine and cases of the delta variant surge, those living with compromised immune systems have a dire plea: consider the safety of others.

Jennifer Browning, Nicole Arneson and Laura Ellsworth are three friends living in Clark County who have all had kidney transplants. For them, life during the pandemic means strictly following the same COVID measures mandated for the general public before a vaccine ever became available.

“We don’t do the things that vaccinated people are doing and because we’ve been told by our medical providers that you need to continue to live as if you’ve been unvaccinated,” said Ellsworth.”

Watch the interview here.

julio 31, 2021agosto 16, 2022

NKF Publishes Recommendations to Move Thousands of Patients from Dialysis to Transplant

“The National Kidney Foundation (NKF) releases today a position paper developed by 16 experts in nephrology and transplantation from 13 institutions that plots a path for research and innovation to address the most pressing barriers to kidney transplant access, organ availability, and long-term allograft survival in the United States.

This ambitious agenda seeks to direct research investment to optimize equity, efficiency, and patient-centered outcomes and maximize the benefits of transplantation in our country. Today, while nearly 100,000 people are on the waitlist for a kidney transplant, only 22,817 Americans received a kidney transplant in 2020.

“While kidney transplantation provides the best treatment option for kidney failure to thousands of patients each year, the goal of universal access to this treatment remains elusive,” said lead author Krista L. Lentine, MD, PhD, Saint Louis University Center for Abdominal Transplantation. “Addressing the priorities outlined in this research agenda has the potential to transform kidney patient care by expanding opportunities for safe living donation, improving waitlist access and transplant readiness, maximizing use of available deceased donor organs, and extending graft longevity.”

To assess the knowledge gaps amenable to more research, NKF convened an expert panel to develop a research agenda aimed at advancing access to kidney transplantation for all patients who could benefit, with attention to reducing/eliminating racial and ethnic disparities and supporting the goal of “one transplant for life” for organ recipients.”

Read full article, here.

julio 30, 2021julio 30, 2021

Call in the T-Cell Cavalry to Fight COVID in the Immunocompromised

“Last year was one of collective confinement. The majority of us shuttered our doors to visitors, worked from home, and ventured out sparingly in hopes of evading the grasp of COVID-19. Now in 2021, thanks to vaccination rollout, those who have been vaccinated are hopefully on the path to normalcy. But not everyone is so fortunate. For some, 2021 will bring more isolation and loneliness than ever before, which is hard to imagine. I’m talking about immunocompromised adults and children. While much of the rest of the populace clinks glasses, hugs loved ones, and joins parties, immunocompromised individuals do not have the security of an effective vaccine, and for their health and safety will maintain their distance and watch the social revelry from the sidelines.”

Liver Transplants: ‘Collateral Damage’ of Pandemic Drinking

“The number of alcoholic hepatitis patients getting liver transplant more than tripled during the COVID-19 pandemic, a retrospective study found.

A difference-in-difference analysis from June 2020 to February 2021 found that liver transplants for acute alcohol-associated hepatitis more than tripled (268.5% increase) compared with expected trends, while the rate of patients with acute alcohol-associated hepatitis added to the transplant waiting list more than quadrupled (325% increase), reported Therese Bittermann, MD, of the University of Pennsylvania in Philadelphia, and colleagues.”

Read full article, here.

julio 29, 2021agosto 16, 2022

SGLT2 Inhibitor Adds Years of Life to Patients With Heart Failure

“Patients with heart failure with reduced ejection fraction (HFrEF) may increase their lifespan if they take the SGLT2 inhibitor dapagliflozin (Farxiga) over the long term, a statistical modeling study showed.

Mean event-free survival was an estimated 8.3 years in a patient with HFrEF who started dapagliflozin at age 65. As a similar patient on standard therapy alone would only be expected to live free from heart failure events for another 6.2 years, this represented an event-free survival time gain of 2.1 years (P=0.002).”

Learn more, here.

julio 29, 2021agosto 16, 2022

If You’ve Done This, Your Risk of COVID After Vaccination Is 82 Times Higher

“A study published July 23 in the Transplantation journal looked at COVID infections among transplant recipients. The researches analyzed data from more than 18,000 fully vaccinated people who had transplants for large organs from 17 transplant centers across the U.S. There were 151 breakthrough infections among the patients studied. According to the researchers, the risk of getting COVID after vaccination is 82 times higher for people who have had a transplant.

Out of the transplant breakthrough infections, 87 people were also hospitalized and 14 died. According to the study, this translates to a 485 times higher risk of breakthrough infection with associated hospitalization and death for transplant recipients. Per the CDC, most people who get breakthrough infections should not expect severe complications.

Study co-author Dorry Segev, MD, a transplant surgeon with Johns Hopkins University, told Science magazine that this is the first study to provide clinical evidence across multiple hospitals that transplant recipients are less protected by the vaccine.”

Read the full article, here.

julio 28, 2021julio 28, 2021

CDC Urges Vaccinated People To Mask Up Indoors In Places With High Virus Transmission

“The Centers for Disease Control and Prevention revised its guidance on wearing masks Tuesday. In a reversal of its earlier position, the agency is now recommending that some fully vaccinated people wear masks indoors if they live in areas with significant or high spread.

Currently, much of the country falls into that category — with the exception of the Northeast and parts of the Upper Midwest. The CDC provides this link if you want to see the area of spread in the county where you live.

“This was not a decision that was taken lightly,” said Dr. Rochelle Walensky, the CDC’s director, acknowledging that people are “tired and frustrated.”

But Walensky pointed to new data showing that while vaccinated people still account for a small amount of risk, in rare cases they can get infected and spread the virus to others.”

Organ Transplant and Skin Cancer Risk

What Patients Need to Know

“Organ transplant patients are at a higher risk — up to a 100-fold higher — for developing skin cancer compared to the general population. Transplant patients tend to develop a skin cancer called squamous cell carcinoma and Kaposi sarcoma. Many patients also develop a skin cancer called basal cell carcinoma and melanoma.

This higher risk is caused by immunosuppressive medications, which are essential to transplant patients to prevent graft rejection and optimize graft survival. Because these medications suppress the immune system that fights off infection and prevents the development of cancer, transplant recipients are at elevated risk for infection and certain cancers.”

Learn more information, here.